Recombinant Human PCSK9 (30-692) Protein
Cat.No. : | PCSK915495H |
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Description : | PCSK9 was expressed and purified from insect cells. The protein was expressed as a HIS-fusion protein and purified by a 2-step chromatographic procedure comprising affinity and size exclusion chromatography steps. |
Species : | Human |
Molecular Mass : | 71.8 kDa |
Purity : | > 90% |
Storage : | frozen; -80 |
Storage Buffer : | 25 mM HEPES pH 7.5;150 mM NaCl 5% glycerol |
Gene Name : | PCSK9 (30-692) |
Official Symbol : | PCSK9 |
Synonyms : | Proprotein Convertase Subtilisin/Kexin Type 9; Subtilisin/Kexin-Like Protease PC9; NARC-1; NARC1; PC9; Convertase Subtilisin/Kexin Type 9 Preproprotein; Hypercholesterolemia; Autosomal Dominant 3; Neural Apoptosis Regulated Convertase 1; Neural Apoptosis-Regulated Convertase 1; |
Gene ID : | 255738 |
UniProt ID : | Q8NBP7 |
Products Types
◆ Recombinant Protein | ||
PCSK9-1257R | Acitve Recombinant Rat PCSK9 protein(Met1-Gln691), His-tagged | +Inquiry |
PCSK9-405C | Recombinant Cynomolgus monkey PCSK9 Protein, His-tagged | +Inquiry |
PCSK9-414R | Recombinant Rhesus macaque PCSK9 Protein, His-tagged | +Inquiry |
PCSK9-135H | Recombinant Human PCSK9 Protein, His-tagged | +Inquiry |
PCSK9-040H | Active Recombinant Human PCSK9 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
PCSK9-2875HCL | Recombinant Human PCSK9 cell lysate | +Inquiry |
PCSK9-2775RCL | Recombinant Rhesus PCSK9 cell lysate | +Inquiry |
PCSK9-2306RCL | Recombinant Rat PCSK9 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1806 | PCSK9(D374T)-LDLR TR-FRET Assay Kit | +Inquiry |
Kit-1808 | PCSK9-LDLR TR-FRET Assay Kit | +Inquiry |
Kit-1807 | PCSK9[Biotinylated]-LDLR Binding Assay Kit | +Inquiry |
Kit-0665 | PCSK9-BIRC2 in vitro Binding Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionYes, some studies suggest that mutations in the PCSK9 protein gene may increase the risk of cardiovascular disease. For example, some PCSK9 mutations can cause their dysfunction, resulting in hypercholesterolemia and cardiovascular disease.
PCSK9 protein is combined with immune adjuvants to make a vaccine, or mutated PCSK9 protein to induce an immune response to it, inhibit PCSK9 expression in vivo, increase LDLR levels and reduce serum cholesterol levels.
This protein may have a regulatory effect on weight and obesity, and it is associated with glucose and endocannabinin homeostasis studies have linked PCSK9 to the development of obesity and diabetes.
Several new anti-PCSK9 drugs are already being studied and developed, including oral drugs and gene chromosome therapies, and some drugs have advanced to early stages of clinical trials, providing new options for the treatment of PCSK9 proteins.
Currently on the market to inhibit PCSK9 protein drugs include alirocumab and evolocumab.
PCSK9 protein can degrade LDLR protein, so its overexpression will lead to a decrease in LDLR's ability to be cleared, leading to hypercholesterolemia.
Customer Reviews (3)
Write a reviewIn immunological experiments, it was found that it had good antigenicity and could induce target immune responses.
It promoted cell growth and proliferation.
High catalytic efficiency.
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