Active Recombinant Human PDGFB protein, Animal-Free
Cat.No. : | PDGFB-312H |
Product Overview : | Recombinant Human PDGFB was expressed in E. coli. Manufactured using all non-animal reagents. |
- Specification
- Gene Information
- Related Products
Description : | PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. |
Source : | E. coli |
Species : | Human |
Bio-activity : | Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells.The expected ED50 for this effect is 1.0-3.0 ng/ml. |
Molecular Mass : | 24.3 kDa |
AA Sequence : | SLGSLTIAE PAMIAECKT RTEVFEISR RLIDRTNAN FLVWPPCVE VQRCSGCCN NRNVQCRPT QVQLRPVQV RKIEIVRKK PIFKKATVT LEDHLACKC ETVAAARPV T |
Purity : | Above 98% as determined by SDS-PAGE Analysis. |
Gene Name : | PDGFB platelet-derived growth factor beta polypeptide [ Homo sapiens ] |
Official Symbol : | PDGFB |
Synonyms : | PDGFB; platelet-derived growth factor beta polypeptide; platelet derived growth factor beta polypeptide (simian sarcoma viral (v sis) oncogene homolog) , SIS; platelet-derived growth factor subunit B; becaplermin; oncogene SIS; SSV; PDGF-2; PDGF, B chain; PDGF subunit B; proto-oncogene c-Sis; platelet-derived growth factor 2; platelet-derived growth factor B chain; platelet-derived growth factor, B chain; Platelet-derived growth factor, beta polypeptide (oncogene SIS); platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); SIS; PDGF2; c-sis; FLJ12858; |
Gene ID : | 5155 |
mRNA Refseq : | NM_002608 |
Protein Refseq : | NP_002599 |
MIM : | 190040 |
UniProt ID : | P01127 |
Chromosome Location : | 22q13.1 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Downstream signal transduction, organism-specific biosystem; Focal Adhesion, organism-specific biosystem; Focal adhesion, organism-specific biosystem; Focal adhesion, conserved biosystem; Gap junction, organism-specific biosystem; |
Function : | cell surface binding; collagen binding; eukaryotic cell surface binding; growth factor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; contributes_to platelet-derived growth factor receptor binding; platelet-derived growth factor receptor binding; platelet-derived growth factor receptor binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein tyrosine kinase activity; superoxide-generating NADPH oxidase activator activity; |
Products Types
◆ Recombinant Protein | ||
PDGFB-1174H | Recombinant Human PDGFB Protein, His-tagged | +Inquiry |
PDGFB-924C | Recombinant Canine PDGFB Protein (Ser82-Thr190), His-tagged | +Inquiry |
PDGFB-1175P | Recombinant Pig PDGFB Protein, His-tagged | +Inquiry |
PDGFB-4403F | Recombinant Feline PDGFB Protein | +Inquiry |
PDGFB-99R | Recombinant Rabbit PDGFB Protein | +Inquiry |
◆ Lysates | ||
PDGFB-1321HCL | Recombinant Human PDGFB cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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