Recombinant Human PDHA1, His-tagged

• Cat.No.: PDHA1-1613H
• Product Overview: Recombinant Human PDHA1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 41-390aa
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 [ Homo sapiens ]
• Official Symbol: PDHA1
• Synonyms: PDHA1; pyruvate dehydrogenase (lipoamide) alpha 1; PDHA; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; pyruvate dehydrogenase complex, E1-alpha polypeptide 1; PHE1A; PDHCE1A
• Gene ID: 5160
• mRNA Refseq: NM_000284
• Protein Refseq: NP_000275
• MIM: 300502
• UniProt ID: P08559
• Chromosome Location: Xp22.1
• Pathway: Acetylcholine Synthesis, organism-specific biosystem; Butanoate metabolism, organism-specific biosystem; Butanoate metabolism, conserved biosystem; Citrate cycle (TCA cycle), organism-specific biosystem; Citrate cycle (TCA cycle), conserved biosystem; Glycolysis / Gluconeogenesis, organism-specific biosystem; Glycolysis / Gluconeogenesis, conserved biosystem
• Function: oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; pyruvate dehydrogenase (acetyl-transferring) activity; pyruvate dehydrogenase activity

Reviews

06/27/2020

Incorporating the PDHA1 protein into your research will not only meet but exceed your expectations, enabling you to advance your scientific discoveries with confidence.

02/28/2019

Researchers can leverage the unique properties of the PDHA1 protein to gain insights into its biological functions and its impact on disease mechanisms.

07/10/2017

It has been shown to play a crucial role in multiple cellular processes, making it highly valuable for investigations into cell signaling, inflammation, and immune responses.

Q&As

What are the symptoms of PDHA1-related disorders?

Symptoms may include developmental delay, intellectual disability, muscle weakness, and movement disorders.

What are the treatment options for PDHA1-related disorders?

Treatment may involve dietary modifications, supplements, and supportive therapies to manage symptoms.

Are there any ongoing research efforts related to PDHA1 protein?

Yes, researchers are studying potential gene therapy approaches and novel treatments for PDHA1-related disorders.

How does the PDHA1 protein impact brain function?

The PDHA1 protein is critical for supplying energy to the brain, and mutations can lead to neurological impairments.

How does a mutation in the PDHA1 gene affect human health?

Mutations in the PDHA1 gene can lead to pyruvate dehydrogenase complex deficiency, resulting in neurological and developmental problems.