Recombinant Human PECAM1 Protein, C-His-tagged

• Cat.No.: PECAM1-114H
• Product Overview: Recombinant Human PECAM1 Protein with C-His tag was expressed in E. coli.

Specification

• Description: CD31 (Platelet Endothelial Cell Adhesion Molecule-1: PECAM-1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating platelets, monocytes, neutrophils, some T cells, and endothelial cells and modulates cell adhesion, endothelial cell migration, and angiogenesis. CD31 is phosphorylated on Tyr686 at the cytoplasmic carboxy-terminal tail upon various stimuli (e.g. mechanical or oxidative stress), presumably by Src family members. The tyrosine phosphorylation mediates associations with a number of SH2 domain-containing binding partners such as PI3 kinase, SHIP, PLCγ, and SHP-2. Thus, CD31 serves as a scaffold for various signaling molecules.
• Source: E. coli
• Species: Human
• Tag: C-His
• Molecular Mass: ~63 kDa
• AA Sequence: QENSFTINSVDMKSLPDWTVQNGKN LTLQCFADVSTTSHVKPQHQMLFYK DDVLFYNISSMKSTESYFIPEVRIY DSGTYKCTVIVNNKEKTTAEYQVLV EGVPSPRVTLDKKEAIQGGIVRVNC SVPEEKAPIHFTIEKLELNEKMVKL KREKNSRDQNFVILEFPVEEQDRVL SFRCQARIISGIHMQTSESTKSELV TVTESFSTPKFHISPTGMIMEGAQL HIKCTIQVTHLAQEFPEIIIQKDKA IVAHNRHGNKAVYSVMAMVEHSGNY TCKVESSRISKVSSIVVNITELFSK PELESSFTHLDQGERLNLSCSIPGA PPANFTIQKEDTIVSQTQDFTKIAS KSDSGTYICTAGIDKVVKKSNTVQI VVCEMLSQPRISYDAQFEVIKGQTI EVRCESISGTLPISYQLLKTSKVLE NSTKNSNDPAVFKDNPTEDVEYQCV ADNCHSHAKMLSEVLRVKVIAPVDE VQISILSSKVVESGEDIVLQCAVNE GSGPITYKFYREKEGKPFYQMTSNA TQAFWTKQKASKEQEGEYYCTAFNR ANHASSVPRSKILTVRVILAPWKK
• Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
• Notes: For research use only, not for use in diagnostic procedure.
• Storage: Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.
• Concentration: ≥0.5 mg/mL
• Storage Buffer: PBS, 4M Urea, pH7.4

Gene Information

• Gene Name: PECAM1 platelet/endothelial cell adhesion molecule 1 [ Homo sapiens (human) ]
• Official Symbol: PECAM1
• Synonyms: PECAM1; platelet/endothelial cell adhesion molecule 1; platelet/endothelial cell adhesion molecule; platelet endothelial cell adhesion molecule; CD31; CD31 antigen; PECA1; GPIIA; PECAM-1; endoCAM; CD31/EndoCAM; FLJ34100; FLJ58394
• Gene ID: 5175
• mRNA Refseq: NM_000442
• Protein Refseq: NP_000433
• MIM: 173445
• UniProt ID: P16284