Recombinant Human PELI2 Protein (F2-D420), His tagged

• Cat.No.: PELI2-0413H
• Product Overview: Recombinant Human 6His-TEV-(GG)-PELI2(F2-D420 end) Protein was expressed in E. coli.

Specification

• Description: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid
• Protein Length: F2-D420
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 75%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol, 1mM DTT.
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: PELI2 pellino E3 ubiquitin protein ligase family member 2 [ Homo sapiens (human) ]
• Official Symbol: PELI2
• Synonyms: PELI2; pellino E3 ubiquitin protein ligase family member 2; pellino (Drosophila) homolog 2, pellino homolog 2 (Drosophila); E3 ubiquitin-protein ligase pellino homolog 2; pellino-2; pellino homolog 2; protein pellino homolog 2
• Gene ID: 57161
• mRNA Refseq: NM_021255
• Protein Refseq: NP_067078
• UniProt ID: Q9HAT8