Recombinant Human PGA4 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: PGA4-1278H
• Product Overview: PGA4 MS Standard C13 and N15-labeled recombinant protein (NP_001073276) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 42 kDa
• AA Sequence: MKWLLLLGLVALSECIMYKVPLIRK KSLRRTLSERGLLKDFLKKHNLNPA RKYFPQWEAPTLVDEQPLENYLDME YFGTIGIGTPAQDFTVVFDTGSSNL WVPSVYCSSLACTNHNRFNPEDSST YQSTSETVSITYGTGSMTGILGYDT VQVGGISDTNQIFGLSETEPGSFLY YAPFDGILGLAYPSISSSGATPVFD NIWNQGLVSQDLFSVYLSADDKSGS VVIFGGIDSSYYTGSLNWVPVTVEG YWQITVDSITMNGETIACAEGCQAI VDTGTSLLTGPTSPIANIQSDIGAS ENSDGDMVVSCSAISSLPDIVFTIN GVQYPVPPSAYILQSEGSCISGFQG MNVPTESGELWILGDVFIRQYFTVF DRANNQVGLAPVATRTRPLEQKLIS EEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: PGA4 pepsinogen A4 [ Homo sapiens (human) ]
• Official Symbol: PGA4
• Synonyms: PGA4; pepsinogen A4; pepsin A-4; pepsinogen 4, group I (pepsinogen A); pepsinogen-4; pregnancy-associated glycoprotein; EC 3.4.23.1
• Gene ID: 643847
• mRNA Refseq: NM_001079808
• Protein Refseq: NP_001073276
• MIM: 169720
• UniProt ID: P0DJD7