Recombinant Human PIK3CB/PIK3R2 Protein, His-tagged

• Cat.No.: PIK3CB-01H
• Product Overview: This PIK3CB/PIK3R2 (p110 beta/p85 beta) recombinant human protein (full length) with His tag was expressed in insect cells.

Specification

• Description: PIK3CB/PIK3R2 lipid kinase (p110 beta/p85 beta) or Phosphatidylinositol 3-kinase (PI3K) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids which functions in signaling pathways that regulate cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kDa catalytic subunit and a 85-kDa adaptor subunit. PIK3CB plays a critical role in regulating the formation and stability of alpha-2B-beta-3 integrin adhesion bonds, which are necessary for shear force-induced platelet activation. PIK3CB sustains alpha-2B-beta-3 integrin activation and stabilized platelet aggregation by regulating both integrin-dependent calcium flux and Gi activation of RAP1B.
• Source: Insect cell
• Species: Human
• Tag: His
• Form: Liquid
• Molecular Mass: 123.7 kDa/83.5 kDa
• Applications: Validated for use with the Adapta assay
  Available in multiple pack sizes for convenient use
  Also available in our SelectScreen Kinase Profiling Service
• Storage Buffer: 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol.

Gene Information

• Gene Name: PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [ Homo sapiens (human) ]
• Official Symbol: PIK3CB
• Synonyms: PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; PI3K; PIK3C1; P110BETA; PI3KBETA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; PI3-kinase p110 subunit beta; PI3-kinase subunit beta; PI3K-beta; PtdIns-3-kinase p110; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphoinositide-3-kinase, catalytic, beta polypeptide; ptdIns-3-kinase subunit beta; ptdIns-3-kinase subunit p110-beta; serine/threonine protein kinase PIK3CB; EC 2.7.1.153; EC 2.7.11.1
• Gene ID: 5291
• mRNA Refseq: NM_006219
• Protein Refseq: NP_006210
• MIM: 602925
• UniProt ID: P42338