Recombinant Human PIK3CD

• Cat.No.: PIK3CD-29587TH
• Product Overview: Human Recombinant full length PI 3 Kinase p110 delta derived from Sf9 insect cells with tag, 120 kDa. The p85 alpha chain is 84 kDa.

Specification

• Description: Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.
• Tissue specificity: Expressed predominantly in leukocytes.
• Biological activity: Activity: 3 nmol/mg/min using phosphatidylinositol as the substrate.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol, 50mM Sodium chloride, 25mM Tris, 0.5mM Magnesium chloride, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the PI3/PI4-kinase family.Contains 1 PI3K/PI4K domain.

Gene Information

• Gene Name: PIK3CD phosphoinositide-3-kinase, catalytic, delta polypeptide [ Homo sapiens ]
• Official Symbol: PIK3CD
• Synonyms: PIK3CD; phosphoinositide-3-kinase, catalytic, delta polypeptide; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform; p110D; phosphatidylinositol 3 kinase; catalytic; delta polypeptide; phosphoinositide 3 kinase C
• Gene ID: 5293
• mRNA Refseq: NM_005026
• Protein Refseq: NP_005017
• MIM: 602839
• Uniprot ID: O00329
• Chromosome Location: 1p36.2
• Pathway: 3-phosphoinositide biosynthesis, conserved biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem
• Function: 1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-3-kinase activity; ATP binding; binding; kinase activity