Recombinant Human PLCB3, His-tagged

• Cat.No.: PLCB3-27922TH
• Product Overview: Recombinant fragment, corresponding to amino acids 1021-1234 of Human Phospholipase C beta 3 with an N terminal His tag. Predicted MWt: 26 kDa

Specification

• Description: This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.
• Conjugation: HIS
• Source: E. coli
• Form: Lyophilised:Reconstitute with 165 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: TKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEH LRQALQRLREVVLDANTTQFKRLKEMNEREKKELQKIL DRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSI RRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQEC QEQRARLPQEIRRSLLGEMPEGLGDGPLVACASNGHAP GSSGHLSGADSESQEENTQL

Gene Information

• Gene Name: PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) [ Homo sapiens ]
• Official Symbol: PLCB3
• Synonyms: PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific); 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3
• Gene ID: 5331
• mRNA Refseq: NM_000932
• Protein Refseq: NP_000923
• MIM: 600230
• Uniprot ID: Q01970
• Chromosome Location: 11q13
• Pathway: Activation of Kainate Receptors upon glutamate binding, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem
• Function: calcium ion binding; calmodulin binding; hydrolase activity; phosphatidylinositol phospholipase C activity; phospholipase C activity