| Description : |
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
148.5 kDa |
| AA Sequence : |
MAGAASPCANGCGPGAPSDAEVLHL CRSLEVGTVMTLFYSKKSQRPERKT FQVKLETRQITWSRGADKIEGAIDI REIKEIRPGKTSRDFDRYQEDPAFR PDQSHCFVILYGMEFRLKTLSLQAT SEDEVNMWIKGLTWLMEDTLQAPTP LQIERWLRKQFYSVDRNREDRISAK DLKNMLSQVNYRVPNMRFLRERLTD LEQRSGDITYGQFAQLYRSLMYSAQ KTMDLPFLEASTLRAGERPELCRVS LPEFQQFLLDYQGELWAVDRLQVQE FMLSFLRDPLREIEEPYFFLDEFVT FLFSKENSVWNSQLDAVCPDTMNNP LSHYWISSSHNTYLTGDQFSSESSL EAYARCLRMGCRCIELDCWDGPDGM PVIYHGHTLTTKIKFSDVLHTIKEH AFVASEYPVILSIEDHCSIAQQRNM AQYFKKVLGDTLLTKPVEISADGLP SPNQLKRKILIKHKKLAEGSAYEEV PTSMMYSENDISNSIKNGILYLEDP VNHEWYPHYFVLTSSKIYYSEETSS DQGNEDEEEPKEVSSSTELHSNEKW FHGKLGAGRDGRHIAERLLTEYCIE TGAPDGSFLVRESETFVGDYTLSFW RNGKVQHCRVHSRQDAGTPKFFLTD NLVFDSLYDLITHYQQVPLRCNEFE MRLSEPVPQTNAHESKEWYHASLTR AQAEHMLMRVPRDGAFLVRKRNEPN SYAISFRAEGKIKHCRVQQEGQTVM LGNSEFDSLVDLISYYEKHPLYRKM KLRYPINEEALEKIGTAEPDYGALY EGRNPGFYVEANPMPTFKCAVKALF DYKAQREDELTFTKSAIIQNVEKQE GGWWRGDYGGKKQLWFPSNYVEEMV NPVALEPEREHLDENSPLGDLLRGV LDVPACQIAIRPEGKNNRLFVFSIS MASVAHWSLDVAADSQEELQDWVKK IREVAQTADARLTEGKIMERRKKIA LELSELVVYCRPVPFDEEKIGTERA CYRDMSSFPETKAEKYVNKAKGKKF LQYNRLQLSRIYPKGQRLDSSNYDP LPMWICGSQLVALNFQTPDKPMQMN QALFMTGRHCGYVLQPSTMRDEAFD PFDKSSLRGLEPCAISIEVLGARHL PKNGRGIVCPFVEIEVAGAEYDSTK QKTEFVVDNGLNPVWPAKPFHFQIS NPEFAFLRFVVYEEDMFSDQNFLAQ ATFPVKGLKTGYRAVPLKNNYSEDL ELASLLIKIDIFPAKQENGDLSPFS GTSLRERGSDASGQLFHGRAREGSF ESRYQQPFEDFRISQEHLADHFDSR ERRAPRRTRVNGDNRLTRTRPLEQK LISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
