Recombinant Human PLEKHM2 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | PLEKHM2-5386H |
Product Overview : | PLEKHM2 MS Standard C13 and N15-labeled recombinant protein (NP_055979) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | This gene encodes a protein that binds the plus-end directed microtubule motor protein kinesin, together with the lysosomal GTPase Arl8, and is required for lysosomes to distribute away from the microtubule-organizing center. The encoded protein belongs to the multisubunit BLOC-one-related complex that regulates lysosome positioning. It binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the Salmonella induced filament A effector protein. Naturally occurring mutations in this gene lead to abnormal localization of lysosomes, impaired autophagy flux and are associated with recessive dilated cardiomyopathy and left ventricular noncompaction. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 112.6 kDa |
AA Sequence : | MEPGEVKDRILENISLSVKKLQSYF AACEDEIPAIRNHDKVLQRLCEHLD HALLYGLQDLSSGYWVLVVHFTRRE AIKQIEVLQHVATNLGRSRAWLYLA LNENSLESYLRLFQENLGLLHKYYV KNALVCSHDHLTLFLTLVSGLEFIR FELDLDAPYLDLAPYMPDYYKPQYL LDFEDRLPSSVHGSDSLSLNSFNSV TSTNLEWDDSAIAPSSEDYDFGDVF PAVPSVPSTDWEDGDLTDTVSGPRS TASDLTSSKASTRSPTQRQNPFNEE PAETVSSSDTTPVHTTSQEKEEAQA LDPPDACTELEVIRVTKKKKIGKKK KSRSDEEASPLHPACSQKKCAKQGD GDSRNGSPSLGRDSPDTMLASPQEE GEGPSSTTESSERSEPGLLIPEMKD TSMERLGQPLSKVIDQLNGQLDPST WCSRAEPPDQSFRTGSPGDAPERPP LCDFSEGLSAPMDFYRFTVESPSTV TSGGGHHDPAGLGQPLHVPSSPEAA GQEEEGGGGEGQTPRPLEDTTREAQ ELEAQLSLVREGPVSEPEPGTQEVL CQLKRDQPSPCLSSAEDSGVDEGQG SPSEMVHSSEFRVDNNHLLLLMIHV FRENEEQLFKMIRMSTGHMEGNLQL LYVLLTDCYVYLLRKGATEKPYLVE EAVSYNELDYVSVGLDQQTVKLVCT NRRKQFLLDTADVALAEFFLASLKS AMIKGCREPPYPSILTDATMEKLAL AKFVAQESKCEASAVTVRFYGLVHW EDPTDESLGPTPCHCSPPEGTITKE GMLHYKAGTSYLGKEHWKTCFVVLS NGILYQYPDRTDVIPLLSVNMGGEQ CGGCRRANTTDRPHAFQVILSDRPC LELSAESEAEMAEWMQHLCQAVSKG VIPQGVAPSPCIPCCLVLTDDRLFT CHEDCQTSFFRSLGTAKLGDISAVS TEPGKEYCVLEFSQDSQQLLPPWVI YLSCTSELDRLLSALNSGWKTIYQV DLPHTAIQEASNKKKFEDALSLIHS AWQRSDSLCRGRASRDPWCTRTRPL EQKLISEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | PLEKHM2 pleckstrin homology and RUN domain containing M2 [ Homo sapiens (human) ] |
Official Symbol : | PLEKHM2 |
Synonyms : | PLEKHM2; pleckstrin homology domain containing, family M (with RUN domain) member 2; pleckstrin homology domain-containing family M member 2; KIAA0842; sifA and kinesin-interacting protein; PH domain-containing family M member 2; novel RUN and PH domain-containing protein; salmonella-induced filaments A and kinesin-interacting protein; SifA (Salmonella-induced filaments A) and kinesin-interacting protein; SKIP; RP11-169K16.1; |
Gene ID : | 23207 |
mRNA Refseq : | NM_015164 |
Protein Refseq : | NP_055979 |
MIM : | 609613 |
UniProt ID : | Q8IWE5 |
Products Types
◆ Recombinant Protein | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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