Recombinant Human PLP1 Protein, His&GST-tagged

• Cat.No.: PLP1-1950H
• Product Overview: Recombinant Human PLP1 Protein (Leu129-Phe242) with N-His&GST tag was expressed in E. coli.

Specification

• Description: This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant.
• Source: E. coli
• Species: Human
• Tag: N-His&GST
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 42.0 kDa
  Accurate Molecular Mass: 42 kDa
• Protein length: Leu129-Phe242
• Purity: > 95%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in ddH2O to a concentration ≤0.1 mg/mL. Do not vortex.

Gene Information

• Gene Name: PLP1 proteolipid protein 1 [ Homo sapiens (human) ]
• Official Symbol: PLP1
• Synonyms: PLP1; proteolipid protein 1; PLP, spastic paraplegia 2, uncomplicated, SPG2; myelin proteolipid protein; Pelizaeus Merzbacher disease; lipophilin; major myelin proteolipid protein; PLP; PMD; HLD1; MMPL; SPG2; PLP/DM20
• Gene ID: 5354
• mRNA Refseq: NM_000533
• Protein Refseq: NP_000524
• MIM: 300401
• UniProt ID: P60201