Description : |
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants. |
Protein length : |
630 amino acids |
Molecular Weight : |
95.300kDa inclusive of tags |
Source : |
Wheat germ |
Tissue specificity : |
Expressed in a variety of organs, including muscle, brain, uterus and esophagus. |
Form : |
Liquid |
Purity : |
Proprietary Purification |
Storage buffer : |
pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione |
Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : |
MDEMATTQISKDELDELKEAFAKVDLNSNGFICDYELHEL FKEANMPLPGYKVREIIQKLMLDGDRNKDGKISFDEFVYI FQEVKSSDIAKTFRKAINRKEGICALGGTSELSSEGTQHS YSEEEKYAFVNWINKALENDPDCRHVIPMNPNTDDLFKAV GDGIVLCKMINLSVPDTIDERAINKKKLTPFIIQENLNLA LNSASAIGCHVVNIGAEDLRAGKPHLVLGLLWQIIKIGLF ADIELSRNEALAALLRDGETLEELMKLSPEELLLRWANFH LENSGWQKINNFSADIKDSKAYFHLLNQIAPKGQKEGEPR IDINMSGFNETDDLKRAESMLQQADKLGCRQFVTPADVVS GNPKLNLAFVANLFNKYPALTKPENQDIDWTLLEGETREE RTFRNWMNSLGVNPHVNHLYADLQDALVILQLYERIKVPV DWSKVNKPPYPKLGANMKKLENCNYAVELGKHPAKFSLVG IGGQDLNDGNQTLTLALVWQLMRRYTLNVLEDLGDGQKAN DDIIVNWVNRTLSEAGKSTSIQSFKDKTISSSLAVVDLID AIQPGCINYDLVKSGNLTEDDKHNNAKYAVSMARRIGARV YALPEDLVEVKPKMVMTVFACLMGRGMKRV |
Sequence Similarities : |
Contains 2 actin-binding domains.Contains 4 CH (calponin-homology) domains.Contains 2 EF-hand domains. |