| Description : |
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
90.5 kDa |
| AA Sequence : |
MEPAPARSPRPQQDPARPQEPTMPP PETPSEGRQPSPSPSPTERAPASEE EFQFLRCQQCQAEAKCPKLLPCLHT LCSGCLEASGMQCPICQAPWPLGAD TPALDNVFFESLQRRLSVYRQIVDA QAVCTRCKESADFWCFECEQLLCAK CFEAHQWFLKHEARPLAELRNQSVR EFLDGTRKTNNIFCSNPNHRTPTLT SIYCRGCSKPLCCSCALLDSSHSEL KCDISAEIQQRQEELDAMTQALQEQ DSAFGAVHAQMHAAVGQLGRARAET EELIRERVRQVVAHVRAQERELLEA VDARYQRDYEEMASRLGRLDAVLQR IRTGSALVQRMKCYASDQEVLDMHG FLRQALCRLRQEEPQSLQAAVRTDG FDEFKVRLQDLSSCITQGKDAAVSK KASPEAASTPRDPIDVDLPEEAERV KAQVQALGLAEAQPMAVVQSVPGAH PVPVYAFSIKGPSYGEDVSNTTTAQ KRKCSQTQCPRKVIKMESEEGKEAR LARSSPEQPRPSTSKAVSPPHLDGP PSPRSPVIGSEVFLPNSNHVASGAG EAEERVVVISSSEDSDAENSCMEPM ETAEPQSSPAHSSPAHSSPAHSSPV QSLLRAQGASSLPCGTYHPPAWPPH QPAEQAATPDAEPHSEPPDHQERPA VHRGIRYLLYRAQRAIRLRHALRLH PQLHRAPIRTWSPHVVQASTPAITG PLNHPANAQEHPAQLQRGISPPHRI RGAVRSRSRSLRGSSHLSQWLNNFF ALPFSSMASQLDMSSVVGAGESRAQ TLGAGVPPGDSVRGSMEASQVQVPL EASPITFPPPCAPERPPISPVPGAR QAGLSGPTRTRRLEQKLISEEDLAA NDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
