Recombinant Human PPARA Protein, His-tagged

• Cat.No.: PPARA-02H
• Product Overview: Recombinant human full length PPARα ligand-binding domain (170-430) with a His tag was expressed in E. coli.

Specification

• Description: Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: ~34 kDa/subunit
• Purity: ≥55%
• Stability: ≥ 1 year
• Storage: At -80 centigrade.
• Storage Buffer: 50 mM sodium phosphate, pH 7.2, with 20% glycerol and 100 mM sodium chloride

Gene Information

• Gene Name: PPARA peroxisome proliferator activated receptor alpha [ Homo sapiens (human) ]
• Official Symbol: PPARA
• Synonyms: PPARA; peroxisome proliferator activated receptor alpha; PPAR; NR1C1; hPPAR; PPARalpha; peroxisome proliferator-activated receptor alpha; PPAR-alpha; nuclear receptor subfamily 1 group C member 1; peroxisome proliferative activated receptor, alpha; peroxisome proliferator-activated nuclear receptor alpha variant 3
• Gene ID: 5465
• mRNA Refseq: NM_005036
• Protein Refseq: NP_005027
• MIM: 170998
• UniProt ID: Q07869