Recombinant Human PRCC Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: PRCC-4079H
• Product Overview: PRCC MS Standard C13 and N15-labeled recombinant protein (NP_005964) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 52.4 kDa
• AA Sequence: MSLVAYASSDESEPDEAEPEPEEEE AVAPTSGPALGGLFASLPAPKGPAL LPPPPQMLAPAFPPPLLLPPPTGDP RLQPPPPLPFGLGGFPPPPGVSPAE AAGVGEGLGLGLPSPRGPGLNLPPP IGGAGPPLGLPKPKKRKEPVKIAAP ELHKGDSDSEEDEPTKKKTILQGSS EGTGLSALLPQPKNLTVKETNRLLL PHAFSRKPSDGSPDTKPSRLASKTK TSSLAPVVGTTTTTPSPSAIKAAAK SAALQVTKQITQEEDDSDEEVAPEN FFSLPEKAEPPGVEPYPYPIPTVPE ELPPGTEPEPAFQDDAANAPLEFKM AAGSSGAPWMPKPGDDYSYNQFSTY GDANAAGAYYQDYYSGGYYPAQDPA LVPTQEIAPDASFIDDEAFKRLQGK RNRGREEINFVEIKGDDQLSGAQQW MTKSLTEEKTMKSFSKKKGEQPTGQ QRRKHQITYLIHQAKERELELKNTW SENKLSRRQTQAKYGFTRTRPLEQK LISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: PRCC proline rich mitotic checkpoint control factor [ Homo sapiens (human) ]
• Official Symbol: PRCC
• Synonyms: PRCC; papillary renal cell carcinoma (translocation-associated); proline-rich protein PRCC; RCCP1; papillary renal cell carcinoma translocation-associated gene protein; TPRC; MGC4723; MGC17178
• Gene ID: 5546
• mRNA Refseq: NM_005973
• Protein Refseq: NP_005964
• MIM: 179755
• UniProt ID: Q92733