Recombinant Human PRKAB2 Protein (Lys17-Lys260), His tagged

• Cat.No.: PRKAB2-5985H
• Product Overview: Recombinant human PRKAB2 (Lys17-Lys260) fused with His tag was expressed in E. coli.

Specification

• Description: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 27.93 kDa
• Protein Length: Lys17-Lys260
• Purity: > 90 % as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit [ Homo sapiens (human) ]
• Official Symbol: PRKAB2
• Synonyms: PRKAB2; protein kinase, AMP-activated, beta 2 non-catalytic subunit; 5-AMP-activated protein kinase subunit beta-2; AMPK beta 2; AMPK beta-2 chain; AMPK subunit beta-2; 5-AMP-activated protein kinase, beta-2 subunit; MGC61468
• Gene ID: 5565
• mRNA Refseq: NM_005399
• Protein Refseq: NP_005390
• MIM: 602741
• UniProt ID: O43741