Recombinant Human PRKAR1A, His-tagged
Cat.No. : | PRKAR1A-7014H |
Product Overview : | Recombinant full-length human PRKAR1A Protein was expressed in Sf9 insect cells using a C-terminal His tag. |
- Specification
- Gene Information
- Related Products
Description : | PRKAR1A or the cAMP-dependent protein kinase regulatory subunit type I alpha, is part of the type 1 PKA holoenzyme. PRKAR1A is found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in PRKAR1A gene cause Carney complex (CNC) and PRKAR1A can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). |
Source : | Sf9 Cells |
Species : | Human |
Tag : | His |
Form : | Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Molecular Mass : | ~51 kDa |
Protein length : | Full length |
Purity : | >85% |
Applications : | Western Blot |
Storage : | Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.2 μg/μl |
Gene Name : | PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) [ Homo sapiens ] |
Official Symbol : | PRKAR1A |
Synonyms : | PRKAR1A; protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1); PRKAR1, TSE1; cAMP-dependent protein kinase type I-alpha regulatory subunit; tissue-specific extinguisher 1; protein kinase A type 1a regulatory subunit; cAMP-dependent protein kinase regulatory subunit RIalpha; cAMP-dependent protein kinase type I-alpha regulatory chain; CAR; CNC; CNC1; PKR1; TSE1; ADOHR; PPNAD1; PRKAR1; MGC17251; DKFZp779L0468; |
Gene ID : | 5573 |
mRNA Refseq : | NM_002734 |
Protein Refseq : | NP_002725 |
MIM : | 188830 |
UniProt ID : | P10644 |
Chromosome Location : | 17q23-q24 |
Pathway : | Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Aquaporin-mediated transport, organism-specific biosystem; Ca-dependent events, organism-specific biosystem; CaM pathway, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calmodulin induced events, organism-specific biosystem; |
Function : | cAMP binding; cAMP-dependent protein kinase regulator activity; nucleotide binding; protein binding; ubiquitin protein ligase binding; |
Products Types
◆ Recombinant Protein | ||
PRKAR1A-2951H | Recombinant Human PRKAR1A Protein, MYC/DDK-tagged | +Inquiry |
PRKAR1A-1763H | Recombinant Human PRKAR1A Protein, His (Fc)-Avi-tagged | +Inquiry |
PRKAR1A-868M | Recombinant Mouse PRKAR1A Protein (Met1-Val381), His-tagged | +Inquiry |
PRKAR1A-4333R | Recombinant Rat PRKAR1A Protein, His (Fc)-Avi-tagged | +Inquiry |
Prkar1a-5114M | Recombinant Mouse Prkar1a Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
PRKAR1A-1009HCL | Recombinant Human PRKAR1A cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket