Recombinant Human PROC therapeutic protein
Cat.No. : | PROC-P027H |
Product Overview : | Recombinant Human activated protein C therapeutic protein is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis. |
Species : | Human |
Molecular Mass : | 55000 |
AA Sequence : | >Heavy chainLIDGKMTRRGDSPWQVVLLD SKKKLACGAVLIHPSWVLTAAHCMD ESKKLLVRLGEYDLRRWEKWELDLD IKEVFVHPNYSKSTTDNDIALLHLA QPATLSQTIVPICLPDSGLAERELN QAGQETLVTGWGYHSSREKEAKRNR TFVLNFIKIPVVPHNECSEVMSNMV SENMLCAGILGDRQDACEGDSGGPM VASFHGTWFLVGLVSWGEGCGLLHN YGVYTKVSRYLDWIHGHIRDKEAPQ KSWAP>Light chainSKHVDGDQCLVLPLEHPCAS LCCGHGTCIXGIGSFSCDCRSGWEG RFCQREVSFLNCSLDNGGCTHYCLE EVGWRRCSCAPGYKLGDDLLQCHPA VKFPCGRPWKRMEKKRSHL |
Endotoxin : | < 0.1 EU per μg of the protein |
Purity : | >95% |
Gene Name : | PROC protein C (inactivator of coagulation factors Va and VIIIa) [ Homo sapiens ] |
Official Symbol : | PROC |
Synonyms : | PROC; protein C (inactivator of coagulation factors Va and VIIIa); vitamin K-dependent protein C; autoprothrombin IIA; anticoagulant protein C; blood coagulation factor XIV; PC; APC; PROC1; THPH3; THPH4; |
Gene ID : | 5624 |
mRNA Refseq : | NM_000312 |
Protein Refseq : | NP_000303 |
MIM : | 612283 |
UniProt ID : | P04070 |
Chromosome Location : | 2q13-q14 |
Pathway : | Cell surface interactions at the vascular wall, organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; Gamma-carboxylation of protein precursors, organism-specific biosystem; |
Function : | calcium ion binding; peptidase activity; protein binding; serine-type endopeptidase activity; |
Products Types
◆ Recombinant Protein | ||
PROC-4368R | Recombinant Rat PROC Protein, His (Fc)-Avi-tagged | +Inquiry |
Proc-5137M | Recombinant Mouse Proc Protein, Myc/DDK-tagged | +Inquiry |
PROC-1772H | Recombinant Human PROC Protein, His (Fc)-Avi-tagged | +Inquiry |
PROC-2537H | Recombinant Human PROC protein(51-190 aa), N-SUMO & C-His-tagged | +Inquiry |
PROC-2432R | Recombinant Rat PROC Protein (42-461 aa), His-tagged | +Inquiry |
◆ Native Protein | ||
PROC-272B | Active Native Bovine Activated Protein C | +Inquiry |
Proc-5346M | Native Mouse Protein C | +Inquiry |
PROC-64H | Active Native Human Activated Protein C | +Inquiry |
◆ Lysates | ||
PROC-747MCL | Recombinant Mouse PROC cell lysate | +Inquiry |
PROC-852HCL | Recombinant Human PROC cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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