Recombinant Human Proteasome (Prosome, Macropain) Subunit, Beta Type, 3, His-tagged
Cat.No. : | PSMB3-1540H |
Product Overview : | Recombinant human PSMB3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | PSMB3-1540H |
Description : | The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 50% glycerol, 0.2M NaCl |
Molecular Weight : | 25.1 kDa (225aa), confirmed by MALDI-TOF |
Purity : | > 90% by SDS - PAGE |
Concentration : | 0.25 mg/ml (determined by Bradford assay) |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MSIMSYNGGA VMAMKGKNCV AIAADRRFGI QAQMVTTDFQ KIFPMGDRLY IGLAGLATDV QTVAQRLKFR LNLYELKEGR QIKPYTLMSM VANLLYEKRF GPYYTEPVIA GLDPKTFKPF ICSLDLIGCP MVTDDFVVSG TCAEQMYGMC ESLWEPNMDP DHLFETISQA MLNAVDRDAV SGMGVIVHII EKDKITTRTL KARMD |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Pathways : | APC/C-mediated degradation of cell cycle proteins; APC/C:Cdc20 mediated degradation of Securin; Adaptive Immunity Signaling; Apoptosis; Assembly of the pre-replicative complex; Autodegradation of the E3 ubiquitin ligase COP1; CDK-mediated phosphorylation and removal of Cdc6; CDT1 association with the CDC6:ORC:origin complex; Cell Cycle Checkpoints; Cell Cycle, Mitotic; Cyclin A:Cdk2-associated events at S phase entry; Cyclin E associated events during G1/S transition; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Synthesis of DNA |
Gene Name : | PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 [ Homo sapiens ] |
Official Symbol : | PSMB3 |
Synonyms : | PSMB3; HC10-II; MGC4147; proteasome subunit beta type-3; OTTHUMP00000164161; proteasome chain 13; proteasome theta chain; proteasome component C10-II; proteasome (prosome, macropain) subunit, beta type, 3; Proteasome chain 13; Proteasome component C10-II; Proteasome theta chain; EC 3.4.25.1 |
Gene ID : | 5691 |
mRNA Refseq : | NM_002795 |
Protein Refseq : | NP_002786 |
MIM : | 602176 |
UniProt ID : | P49720 |
Chromosome Location : | 17q12 |
Function : | peptidase activity; protein binding; threonine-type endopeptidase activity |
Products Types
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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