Recombinant Human PRPS1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: PRPS1-5047H
• Product Overview: PRPS1 MS Standard C13 and N15-labeled recombinant protein (NP_002755) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome. Two transcript variants encoding different isoforms have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 34.8 kDa
• AA Sequence: MPNIKIFSGSSHQDLSQKIADRLGL ELGKVVTKKFSNQETCVEIGESVRG EDVYIVQSGCGEINDNLMELLIMIN ACKIASASRVTAVIPCFPYARQDKK DKSRAPISAKLVANMLSVAGADHII TMDLHASQIQGFFDIPVDNLYAEPA VLKWIRENISEWRNCTIVSPDAGGA KRVTSIADRLNVDFALIHKERKKAN EVDRMVLVGDVKDRVAILVDDMADT CGTICHAADKLLSAGATRVYAILTH GIFSGPAISRINNACFEAVVVTNTI PQEDKMKHCSKIQVIDISMILAEAI RRTHNGESVSYLFSHVPLTRTRPLE QKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: PRPS1 phosphoribosyl pyrophosphate synthetase 1 [ Homo sapiens (human) ]
• Official Symbol: PRPS1
• Synonyms: PRPS1; phosphoribosyl pyrophosphate synthetase 1; deafness, X linked 2, perceptive, congenital, DFN2; ribose-phosphate pyrophosphokinase 1; CMTX5; DFNX1; PRS I; ribose phosphate diphosphokinase 1; deafness 2, perceptive, congenital; ribose-phosphate diphosphokinase 1; phosphoribosyl pyrophosphate synthase I; deafness, X-linked 2, perceptive, congenital; dJ1070B1.2 (phosphoribosyl pyrophosphate synthetase 1); ARTS; DFN2; PRSI; PRS-I; PPRibP; KIAA0967
• Gene ID: 5631
• mRNA Refseq: NM_002764
• Protein Refseq: NP_002755
• MIM: 311850
• UniProt ID: P60891