Recombinant Human PRSS1 protein(104-206aa), His-GST-tagged

• Cat.No.: PRSS1-2173H
• Product Overview: Recombinant Human PRSS1 protein(P07477)(104-206aa), fused with N-terminal His and GST tag, was expressed in E.coli.

Specification

• Source: E.coli
• Species: Human
• Tag: N-His-GST
• Protein length: 104-206aa
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 42.1 kDa
• AASequence: LNNDIMLIKLSSRAVINARVSTISL PTAPPATGTKCLISGWGNTASSGAD YPDELQCLDAPVLSQAKCEASYPGK ITSNMFCVGFLEGGKDSCQGDSGGP VVC
• Purity: Greater than 85% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C.

Gene Information

• Gene Name: PRSS1 protease, serine, 1 (trypsin 1) [ Homo sapiens ]
• Official Symbol: PRSS1
• Synonyms: PRSS1; protease, serine, 1 (trypsin 1); TRY1; trypsin-1; beta-trypsin; trypsinogen 1; trypsinogen A; digestive zymogen; cationic trypsinogen; nonfunctional trypsin 1; TRP1; TRY4; TRYP1; FLJ57296; MGC120175; MGC149362; DKFZp779A0837
• Gene ID: 5644
• mRNA Refseq: NM_002769
• Protein Refseq: NP_002760
• MIM: 276000
• UniProt ID: P07477

Reviews

06/02/2023

The pharmacodynamic parameters of PRSS1 were good.

12/20/2022

PRSS1 has very high sensitivity in Western blot and can detect low concentrations of the protein of interest.

05/19/2021

PRSS1 has good compatibility and stability with various excipients.

Q&As

What is the relationship between PRSS1's structure and function?

The structure of PRSS1 determines its ability to bind specifically to the substrate and the efficiency of the catalytic reaction. The study of its structure can help us understand its function and mechanism of action.

What are the interactions between PRSS1 and other digestive enzymes?

PRSS1 can interact with other digestive enzymes, such as stomach acid and bile, to participate in the digestive process of food.

Which is the main function of PRSS1 in the digestive system?

It is primarily involved in the digestion of proteins in the digestive system, breaking them down into small peptides and amino acids.

What are the therapeutic strategies for PRSS1?

Therapeutic strategies for PRSS1 may include supplementing or inhibiting its expression and regulating its interaction with other digestive enzymes. These methods may have potential applications in treating diseases such as pancreatitis or pancreatic cancer.

Why is PRSS1 expressed in the pancreas but not in other organs?

The expression of PRSS1 in the pancreas is determined by factors such as its substrate specificity and synergies with other digestive enzymes. In other organs, its expression may vary by different regulatory mechanisms.

How about the effects of lack or overexpression of PRSS1?

Lack of PRSS1 may lead to protein digestion disorders, while overexpression of PRSS1 may lead to diseases such as pancreatitis or pancreatic cancer.