Recombinant Human PSAP Protein, His-tagged

• Cat.No.: PSAP-01H
• Product Overview: Recombinant Full-length Human Prosaposin (PSAP) with a N-terminal His-tag was produced in Nicotiana benthamiana by Agrobacterium-mediated transient expression.

Specification

• Description: This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
• Source: Nicotiana benthamiana
• Species: Human
• Tag: His
• Form: Lyophilized
• Molecular Mass: 58.1 kDa (+ Glycosylation)
• Purity: 98%
• Storage: Lyophilized materials are stable for up to twelve months from date of receipt at -70 centigrade.
  It is recommended that reconstituted protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS, pH7.4, 175 mM Trehalose.
• Shipping: At ambient temperature.

Gene Information

• Gene Name: PSAP prosaposin [ Homo sapiens (human) ]
• Official Symbol: PSAP
• Synonyms: PSAP; prosaposin; GLBA; SAP1; SAP2; PSAPD; PARK24; prosaposin; proactivator polypeptide; saposin-A; saposin-B; saposin-C; saposin-D; sphingolipid activator protein-1; sphingolipid activator protein-2
• Gene ID: 5660
• mRNA Refseq: NM_002778
• Protein Refseq: NP_002769
• MIM: 176801
• UniProt ID: P07602