Recombinant Human PSMC4, His-tagged
Cat.No. : | PSMC4-29835TH |
Product Overview : | Recombinant full length Human Tbp7 protein with an N terminal His tag. Predicted MWt: 48 kDa; |
- Specification
- Gene Information
- Related Products
Description : | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with an orphan member of the nuclear hormone receptor superfamily highly expressed in liver, and with gankyrin, a liver oncoprotein. Two transcript variants encoding different isoforms have been identified. |
Conjugation : | HIS |
Source : | E. coli |
Form : | Lyophilised:Reconstitute with 84 μl aqua dest. |
Storage buffer : | Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | MEEIGILVEKAQDEIPALSVSRPQT GLSFLGPEPEDLEDL YSRYKKLQQELEFLEVQEEYIKDEQ KNLKKEFLHAQEE VKRIQSIPLVIGQFLEAVDQNTAIV GSTTGSNYYVRIL STIDRELLKPNASVALHKHSNALVD VLPPEADSSIMMLTS DQKPDVMYADIGGMDIQKQEVREAV ELPLTHFELYKQI GIDPPRGVLMYGPPGCGKTMLAKAV AHHTTAAFIRVVG SEFVQKYLGEGPRMVRDVFRLAKEN APAIIFIDEIDAIATKRFDAQTGAD REVQRILLELLNQMDGFDQNVNVKV IMA TNRADTLDPALLRPGRLDRKIEFPL PDRRQKRLIFSTI TSKMNLSEEVDLEDYVARPDKISGA DINSICQESGMLA VRENRYIVLAKDFEKAYKTVIKKDE QEHEFYK |
Gene Name : | PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 [ Homo sapiens ] |
Official Symbol : | PSMC4 |
Synonyms : | PSMC4; proteasome (prosome, macropain) 26S subunit, ATPase, 4; MIP224; 26S protease regulatory subunit 6B; MB67 interacting protein; MGC8570; MGC13687; MGC23214; protease 26S subunit 6; S6; Tat binding protein 7; TBP 7; TBP7; |
Gene ID : | 5704 |
mRNA Refseq : | NM_006503 |
Protein Refseq : | NP_006494 |
MIM : | 602707 |
Uniprot ID : | P43686 |
Chromosome Location : | 19q13.11-q13.13 |
Pathway : | APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; |
Function : | ATP binding; ATPase activity; hydrolase activity; nucleotide binding; protein binding; |
Products Types
◆ Recombinant Protein | ||
PSMC4-4441R | Recombinant Rat PSMC4 Protein, His (Fc)-Avi-tagged | +Inquiry |
PSMC4-417H | Recombinant Human PSMC4 Protein, His-tagged | +Inquiry |
PSMC4-564C | Recombinant Cynomolgus Monkey PSMC4 Protein, His (Fc)-Avi-tagged | +Inquiry |
Psmc4-5186M | Recombinant Mouse Psmc4 Protein, Myc/DDK-tagged | +Inquiry |
PSMC4-7218M | Recombinant Mouse PSMC4 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
PSMC4-2761HCL | Recombinant Human PSMC4 293 Cell Lysate | +Inquiry |
PSMC4-2760HCL | Recombinant Human PSMC4 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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