Recombinant Human PTEN Protein (Met35-Val403), N-His tagged
Cat.No. : | PTEN-6058H |
Product Overview : | Recombinant human PTEN (Met35-Val403) fused with the N-His tag was expressed in E. coli. |
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Source : | E. coli |
Species : | Human |
Tag : | N-His |
Form : | Lyophilized powder/frozen liquid |
Molecular Mass : | 45.43 kDa |
Protein Length : | Met35-Val403 |
Purity : | > 90 % as determined by SDS-PAGE |
Notes : | For research use only. |
Storage : | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
Storage Buffer : | 0.01M PBS, pH 7.4, 0.02 % NLS |
Reconstitution : | Reconstitute in sterile water for a stock solution. |
Shipping : | They are shipped out with dry ice/blue ice unless customers require otherwise. |
Gene Name : | PTEN phosphatase and tensin homolog [ Homo sapiens (human) ] |
Official Symbol : | PTEN |
Synonyms : | PTEN; phosphatase and tensin homolog; BZS, MHAM; phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; MMAC1; mutated in multiple advanced cancers 1; PTEN1; TEP1; phosphatase and tensin-like protein; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; BZS; DEC; GLM2; MHAM; 10q23del; MGC11227; |
Gene ID : | 5728 |
mRNA Refseq : | NM_000314 |
Protein Refseq : | NP_000305 |
MIM : | 601728 |
UniProt ID : | P60484 |
Products Types
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PTEN-7249M | Recombinant Mouse PTEN Protein, His (Fc)-Avi-tagged | +Inquiry |
PTEN-31H | Recombinant Human PTEN Protein, His-tagged | +Inquiry |
PTEN-342H | Recombinant Human PTEN Protein, His-tagged | +Inquiry |
◆ Lysates | ||
PTEN-2721HCL | Recombinant Human PTEN 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionIn addition to its lipid phosphatase activity, PTEN has an additional function known as a scaffolding protein that contributes to its tumor-suppressive role.
PTEN primarily exerts its lipid phosphatase function in the cytoplasm, where it regulates the PI3K/AKT pathway.
The significance of FBXO22-mediated degradation of nuclear PTEN in promoting tumorigenesis involves the loss of PTEN's tumor-suppressive functions, leading to uncontrolled cell growth.
The expression of nuclear PTEN (核PTEN) is regulated, especially in the context of tumorigenesis, through mechanisms involving post-translational modifications and subcellular localization.
Differences in expression patterns of nuclear PTEN and cytoplasmic PTEN in various cancer processes include alterations in nuclear PTEN levels contributing to tumorigenesis.
The classical function of the PTEN protein is to regulate cell growth and prevent tumor formation by suppressing the PI3K/AKT signaling pathway.
Nuclear PTEN plays a role in mediating the non-phosphatase-dependent function related to genomic stability and DNA repair.
Customer Reviews (3)
Write a reviewGel electrophoresis consistently displayed well-defined bands, affirming the product's purity and reliability.
The insights gained from the product's application justified its cost, marking a prudent investment in our research endeavors.
Comprehensive documentation streamlined the integration of the product into our experimental workflow.
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