| Description : |
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
121.5 kDa |
| AA Sequence : |
MISADCNLCLPEYDRYLASSKIMAA AYLDPNLNHTPNSSTKTHLGTGMER SPGAMERVLKVFHYFESNSEPTTWA SIIRHGDATDVRGIIQKIVDSHKVK HVACYGFRLSHLRSEEVHWLHVDMG VSSVREKYELAHPPEEWKYELRIRY LPKGFLNQFTEDKPTLNFFYQQVKS DYMLEIADQVDQEIALKLGCLEIRR SYWEMRGNALEKKSNYEVLEKDVGL KRFFPKSLLDSVKAKTLRKLIQQTF RQFANLNREESILKFFEILSPVYRF DKECFKCALGSSWIISVELAIGPEE GISYLTDKGCNPTHLADFTQVQTIQ YSNSEDKDRKGMLQLKIAGAPEPLT VTAPSLTIAENMADLIDGYCRLVNG TSQSFIIRPQKEGERALPSIPKLAN SEKQGMRTHAVSVSETDDYAEIIDE EDTYTMPSTRDYEIQRERIELGRCI GEGQFGDVHQGIYMSPENPALAVAI KTCKNCTSDSVREKFLQEALTMRQF DHPHIVKLIGVITENPVWIIMELCT LGELRSFLQVRKYSLDLASLILYAY QLSTALAYLESKRFVHRDIAARNVL VSSNDCVKLGDFGLSRYMEDSTYYK ASKGKLPIKWMAPESINFRRFTSAS DVWMFGVCMWEILMHGVKPFQGVKN NDVIGRIENGERLPMPPNCPPTLYS LMTKCWAYDPSRRPRFTELKAQLST ILEEEKAQQEERMRMESRRQATVSW DSGGSDEAPPKPSRPGYPSPRSSEG FYPSPQHMVQTNHYQVSGYPGSHGI TAMAGSIYPGQASLLDQTDSWNHRP QEIAMWQPNVEDSTVLDLRGIGQVL PTHLMEERLIRQQQEMEEDQRWLEK EERFLKPDVRLSRGSIDREDGSLQG PIGNQHIYQPVGKPDPAAPPKKPPR PGAPGHLGSLASLSSPADSYNEGVK LQPQEISPPPTANLDRSNDKVYENV TGLVKAVIEMSSKIQPAPPEEYVPM VKEVGLALRTLLATVDETIPLLPAS THREIEMAQKLLNSDLGELINKMKL AQQYVMTSLQQEYKKQMLTAAHALA VDAKNLLDVIDQARLKMLGQTRPHT RTRPLEQKLISEEDLAANDILDYKD DDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
