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Recombinant Human PTK2B Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : PTK2B-4719H
Product Overview : PTK2B MS Standard C13 and N15-labeled recombinant protein (NP_004094) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
  • Specification
  • Gene Information
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Description : This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 115.9 kDa
AA Sequence : MSGVSEPLSRVKLGTLRRPEGPAEP MVVVPVDVEKEDVRILKVCFYSNSF NPGKNFKLVKCTVQTEIREIITSIL LSGRIGPNIRLAECYGLRLKHMKSD EIHWLHPQMTVGEVQDKYECLHVEA EWRYDLQIRYLPEDFMESLKEDRTT LLYFYQQLRNDYMQRYASKVSEGMA LQLGCLELRRFFKDMPHNALDKKSN FELLEKEVGLDLFFPKQMQENLKPK QFRKMIQQTFQQYASLREEECVMKF FNTLAGFANIDQETYRCELIQGWNI TVDLVIGPKGIRQLTSQDAKPTCLA EFKQIRSIRCLPLEEGQAVLQLGIE GAPQALSIKTSSLAEAENMADLIDG YCRLQGEHQGSLIIHPRKDGEKRNS LPQIPMLNLEARRSHLSESCSIESD IYAEIPDETLRRPGGPQYGIAREDV VLNRILGEGFFGEVYEGVYTNHKGE KINVAVKTCKKDCTLDNKEKFMSEA VIMKNLDHPHIVKLIGIIEEEPTWI IMELYPYGELGHYLERNKNSLKVLT LVLYSLQICKAMAYLESINCVHRDI AVRNILVASPECVKLGDFGLSRYIE DEDYYKASVTRLPIKWMSPESINFR RFTTASDVWMFAVCMWEILSFGKQP FFWLENKDVIGVLEKGDRLPKPDLC PPVLYTLMTRCWDYDPSDRPRFTEL VCSLSDVYQMEKDIAMEQERNARYR TPKILEPTAFQEPPPKPSRPKYRPP PQTNLLAPKLQFQVPEGLCASSPTL TSPMEYPSPVNSLHTPPLHRHNVFK RHSMREEDFIQPSSREEAQQLWEAE KVKMRQILDKQQKQMVEDYQWLRQE EKSLDPMVYMNDKSPLTPEKEVGYL EFTGPPQKPPRLGAQSIQPTANLDR TDDLVYLNVMELVRAVLELKNELCQ LPPEGYVVVVKNVGLTLRKLIGSVD DLLPSLPSSSRTEIEGTQKLLNKDL AELINKMRLAQQNAVTSLSEECKRQ MLTASHTLAVDAKNLLDAVDQAKVL ANLAHPPAETRTRPLEQKLISEEDL AANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : PTK2B PTK2B protein tyrosine kinase 2 beta [ Homo sapiens (human) ]
Official Symbol : PTK2B
Synonyms : PTK2B; PTK2B protein tyrosine kinase 2 beta; FAK2, protein tyrosine kinase 2 beta; protein-tyrosine kinase 2-beta; CADTK; CAKB; PTK; PYK2; RAFTK; FADK 2; CAK-beta; protein kinase B; focal adhesion kinase 2; cell adhesion kinase beta; proline-rich tyrosine kinase 2; calcium-dependent tyrosine kinase; related adhesion focal tyrosine kinase; calcium-regulated non-receptor proline-rich tyrosine kinase; PKB; FAK2; FADK2;
Gene ID : 2185
mRNA Refseq : NM_004103
Protein Refseq : NP_004094
MIM : 601212
UniProt ID : Q14289

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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