Recombinant Human PTPN12, GST-tagged
Cat.No. : | PTPN12-1858H |
Product Overview : | Recombinant human PTPN12 protein(2-300) with N-terminal GST tag was expressed in anE.coliexpression system, MW=61.4 kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | PTPN12-1858H |
Description : | Protein tyrosine phosphatase-PEST (PTPN12), a ubiquitously expressed cytoplasmic tyrosine phosphatase, is thought to play an important role in cell adhesion and motility, cell migration, and signal transduction for antigen receptors in B and T lymphocytes. Signal transduction via tyrosine phosphorylation, normally fine-tuned by the concerted action of both protein tyrosine kinases and protein tyrosine phosphatases (PTPs), is a key mechanism in tumorigenesis. Studies suggest potential role for PTP-PEST in regulation of p130(cas) in mitogen- and cell adhesion-induced signaling events. |
Source : | E.coli. |
Formulation : | 25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione. |
Purity : | > 90% by SDS-PAGE. |
Specific Activity : | 1 U/ug. One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30ºC. Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3 mM DTT, 100 mM NaCl, 50 mM pNPP. |
Application : | Useful for the study of enzyme kinetics, regulation, to dephosphorylate target substrates and for screening inhibitors. |
Storage : | >6 months at –80°C. |
Gene Name : | PTPN12 protein tyrosine phosphatase, non-receptor type 12 [ Homo sapiens ] |
Synonyms : | protein tyrosine phosphatase, non-receptor type 12; PTPG1; PTP-PEST; PTPN12; protein-tyrosine phosphatase G1; tyrosine-protein phosphatase non-receptor type 12; EC 3.1.3.48; OTTHUMP00000025119; Protein-tyrosine phosphatase G1 |
Gene ID : | 5782 |
mRNA Refseq : | NM_001131008 |
Protein Refseq : | NP_001124480 |
MIM : | 600079 |
UniProt ID : | Q05209 |
Chromosome Location : | 7q11.23 |
Function : | SH3 domain binding; hydrolase activity; protein binding; non-membrane spanning protein tyrosine phosphatase activity |
Products Types
◆ Recombinant Protein | ||
Ptpn12-2002M | Recombinant Mouse Ptpn12 Protein, His&GST-tagged | +Inquiry |
PTPN12-3135H | Recombinant Human PTPN12 Protein, MYC/DDK-tagged | +Inquiry |
PTPN12-7276M | Recombinant Mouse PTPN12 Protein, His (Fc)-Avi-tagged | +Inquiry |
Ptpn12-5236M | Recombinant Mouse Ptpn12 Protein, Myc/DDK-tagged | +Inquiry |
PTPN12-411H | Recombinant Human PTPN12, Gly & Pro tagged | +Inquiry |
◆ Lysates | ||
PTPN12-002HCL | Recombinant Human PTPN12 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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