| Description : |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. |
| Source : |
HEK293 |
| Species : |
Human |
| Form : |
Lyophilized |
| Molecular Mass : |
140 kDa |
| Protein Length : |
1912 |
| AA Sequence : |
MVHVARLLLLLLTFFLRTDAETPPR FTRTPVDQTGVSGGVASFICQATGD PRPKIVWNKKGKKVSNQRFEVIEFD DGSGSVLRIQPLRTPRDEAIYECVA SNNVGEISVSTRLTVLREDQIPRGF PTIDMGPQLKVVERTRTATMLCAAS GNPDPEITWFKDFLPVDTSNNNGRI KQLRSESIGGTPIRGALQIEQSEES DQGKYECVATNSAGTRYSAPANLYV RELREVRRVPPRFSIPPTNHEIMPG GSVNITCVAVGSPMPYVKWMLGAED LTPEDDMPIGRNVLELNDVRQSANY TCVAMSTLGVIEAIAQITVKALPKP PGTPVVTESTATSITLTWDSGNPEP VSYYIIQHKPKNSEELYKEIDGVAT TRYSVAGLSPYSDYEFRVVAVNNIG RGPPSEPVLTQTSEQAPSSAPRDVQ ARMLSSTTILVQWKEPEEPNGQIQG YRVYYTMDPTQHVNNWMKHNVADSQ ITTIGNLVPQKTYSVKVLAFTSIGD GPLSSDIQVITQTGVPGQPLNFKAE PESETSILLSWTPPRSDTIANYELV YKDGEHGEEQRITIEPGTSYRLQGL KPNSLYYFRLAARSPQGLGASTAEI SARTMQSKPSAPPQDISCTSPSSTS ILVSWQPPPVEKQNGIITEYSIKYT AVDGEDDKPHEILGIPSDTTKYLLE QLEKWTEYRITVTAHTDVGPGPESL SVLIRTNEDVPSGPPRKVEVEAVNS TSVKVSWRSPVPNKQHGQIRGYQVH YVRMENGEPKGQPMLKDVMLADAQW EFDDTTEHDMIISGLQPETSYSLTV TAYTTKGDGARSKPKLVSTTGAVPG KPRLVINHTQMNTALIQWHPPVDTF GPLQGYRLKFGRKDMEPLTTLEFSE KEDHFTATDIHKGASYVFRLSARNK VGFGEEMVKEISIPEEVPTGFPQNL HSEGTTSTSVQLSWQPPVLAERNGI ITKYTLLYRDINIPLLPMEQLIVPA DTTMTLTGLKPDTTYDVKVRAHTSK GPGPYSPSVQFRTLPVDQVFAKNFH VKAVMKTSVLLSWEIPENYNSAMPF KILYDDGKMVEEVDGRATQKLIVNL KPEKSYSFVLTNRGNSAGGLQHRVT AKTAPDVLRTKPAFIGKTNLDGMIT VQLPEVPANENIKGYYIIIVPLKKS RGKFIKPWESPDEMELDELLKEISR KRRSIRYGREVELKPYIAAHFDVLP TEFTLGDDKHYGGFTNKQLQSGQEY VFFVLAVMEHAESKMYATSPYSDPV VSMDLDPQPITDEEEGLIWVVGPVL AVVFIICIVIAILLYKRKRAESDSR KSSIPNNKEIPSHHPTDPVELRRLN FQTPGMASHPPIPILELADHIERLK ANDNLKFSQEYESIDPGQQFTWEHS NLEVNKPKNRYANVIAYDHSRVLLS AIEGIPGSDYVNANYIDGYRKQNAY IATQGSLPETFGDFWRMIWEQRSAT VVMMTKLEERSRVKCDQYWPSRGTE THGLVQVTLLDTVELATYCVRTFAL YKNGSSEKREVRQFQFTAWPDHGVP EHPTPFLAFLRRVKTCNPPDAGPMV VHCSAGVGRTGCFIVIDAMLERIKH EKTVDIYGHVTLMRAQRNYMVQTED QYIFIHDALLEAVTCGNTEVPARNL YAYIQKLTQIETGENVTGMELEFKR LASSKAHTSRFISANLPCNKFKNRL VNIMPYESTRVCLQPIRGVEGSDYI NASFIDGYRQQKAYIATQGPLAETT EDFWRMLWEHNSTIVVMLTKLREMG REKCHQYWPAERSARYQYFVVDPMA EYNMPQYILREFKVTDARDGQSRTV RQFQFTDWPEQGVPKSGEGFIDFIG QVHKTKEQFGQDGPISVHCSAGVGR TGVFITLSIVLERMRYEGVVDIFQT VKMLRTQRPAMVQTEDQYQFSYRAA LEYLGSFDHYAT |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
