Recombinant Human PTPRF Protein (Asp30-Tyr224), His tagged

• Cat.No.: PTPRF-6106H
• Product Overview: Recombinant human PTPRF (Asp30-Tyr224) fused with His tag was expressed in E. coli.

Specification

• Description: Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 22.11 kDa
• Protein Length: Asp30-Tyr224
• Purity: > 90 % as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: PTPRF protein tyrosine phosphatase, receptor type, F [ Homo sapiens (human) ]
• Official Symbol: PTPRF
• Synonyms: PTPRF; protein tyrosine phosphatase, receptor type, F; LAR; receptor-type tyrosine-protein phosphatase F; LCA-homolog; leukocyte common antigen related; leukocyte antigen-related (LAR) PTP receptor; leukocyte antigen-related tyrosine phosphatase; receptor-linked protein-tyrosine phosphatase LAR; protein tyrosine phosphatase, receptor type, F polypeptide; FLJ43335; FLJ45062; FLJ45567
• Gene ID: 5792
• mRNA Refseq: NM_002840
• Protein Refseq: NP_002831
• MIM: 179590
• UniProt ID: P10586

Reviews

06/11/2022

Qualitative is very strong, even after a lot of use can still maintain its structural and functional stability, which shows its excellent quality and reliability.

04/13/2022

The reproducibility is very good, and I can get consistent results from each experiment, which makes me more confident in the experimental results.

02/19/2022

Excellent performance in Western blot, avoiding interference problems in the experiment.

Q&As

Do specific PTPRF inhibitors have therapeutic effects on autoimmune diseases?

PTPRF inhibitors can inhibit certain abnormal signaling pathways in autoimmune diseases, thereby exerting their role in the treatment of autoimmune diseases.

What is the therapeutic effect of specific PTPRF inhibitors on inflammatory diseases?

Specific PTPRF inhibitors can inhibit certain signaling pathways in the inflammatory response, thereby playing a role in the treatment of inflammatory diseases.

What is the effect of knocking out the PTPRF gene on tumorigenesis?

Knocking out the PTPRF gene may increase the risk of developing certain tumors, which may be related to aberrant regulation of cell cycle control and cell growth.

Is there a specific PTPRF inhibitor?

There are currently some studies that report specific PTPRF inhibitors that can inhibit the enzymatic activity of PTPRF and thus exert therapeutic effects.

Is there a soluble PTPRF protein?

Yes, soluble PTPRF proteins exist that can be detected in extracellular fluids and may play a role in regulating cell-to-cell communication and signal transduction.

What are the therapeutic strategies for PTPRF protein?

Therapeutic strategies for PTPRF protein include increasing its expression level, inhibiting its enzymatic activity, and regulating its interaction with other proteins, which can be used to treat PTPRF protein-related diseases.