Recombinant Human PVRL3 protein, Fc-tagged
Cat.No. : | PVRL3-388H |
Product Overview : | Recombinant Human PVRL3 protein (Gly58-Asp400), fused to human IgG1 Fc tag at C-terminus, was expressed in human 293 cells (HEK293). |
- Specification
- Gene Information
- Related Products
Description : | Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Nectins are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin system in epithelial cells. PVRL3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Furthermore, PVRL3 induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. |
Source : | HEK293 |
Species : | Human |
Tag : | human IgG1 Fc |
Form : | Lyophilized from 0.22 um filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 64.3 kDa. The protein migrates as 80-95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | 343 |
Endotoxin : | Less than 1.0 EU per ug by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | PVRL3 |
Official Symbol : | PVRL3 |
Synonyms : | PVRL3; poliovirus receptor-related 3; poliovirus receptor-related protein 3; CD113; CDw113; DKFZP566B0846; nectin 3; PPR3; PVRR3; PRR3; CDW113; NECTIN-3; FLJ90624; DKFZp566B0846 |
Gene ID : | 25945 |
mRNA Refseq : | NM_001243286 |
Protein Refseq : | NP_001230215 |
MIM : | 607147 |
UniProt ID : | Q9NQS3 |
Products Types
◆ Recombinant Protein | ||
PVRL3-2187H | Active Recombinant Human PVRL3 Protein, Fc-Avi-tagged, Biotinylated | +Inquiry |
PVRL3-3953H | Recombinant Human PVRL3 Protein, His (Fc)-Avi-tagged | +Inquiry |
PVRL3-277H | Recombinant Human PVRL3 Protein (ECD), Fc-His-tagged(C-ter) | +Inquiry |
PVRL3-3275H | Active Recombinant Human PVRL3 protein(Met1-Asp400), His-tagged | +Inquiry |
PVRL3-13733M | Recombinant Mouse Pvrl3 protein, His/T7-tagged | +Inquiry |
◆ Lysates | ||
PVRL3-2643HCL | Recombinant Human PVRL3 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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