Description : |
This gene encodes a nuclear-cytoplasmic pyridine nucleotide-disulphide reductase (PNDR). PNDRs are flavoproteins that catalyze the pyridine nucleotide-dependent reduction of thiol residues in other proteins. The encoded protein belongs to the class I pyridine nucleotide-disulphide oxidoreductase family but lacks the C-terminal dimerization domain found in other family members and instead has a C-terminal nitrile reductase domain. It localizes to the nucleus and to striated sarcomeric compartments. Naturally occurring mutations in this gene cause early-onset myopathy with internalized nuclei and myofibrillar disorganization. A pseudogene of this gene has been defined on chromosome 11. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
55.8 kDa |
AA Sequence : |
MEAARPPPTAGKFVVVGGGIAGVTC AEQLATHFPSEDILLVTASPVIKAV TNFKQISKILEEFDVEEQSSTMLGK RFPNIKVIESGVKQLKSEEHCIVTE DGNQHVYKKLCLCAGAKPKLICEGN PYVLGIRDTDSAQEFQKQLTKAKRI MIIGNGGIALELVYEIEGCEVIWAI KDKAIGNTFFDAGAAEFLTSKLIAE KSEAKIAHKRTRYTTEGRKKEARSK SKADNVGSALGPDWHEGLNLKGTKE FSHKIHLETMCEVKKIYLQDEFRIL KKKSFTFPRDHKSVTADTEMWPVYV ELTNEKIYGCDFIVSATGVTPNVEP FLHGNSFDLGEDGGLKVDDHMHTSL PDIYAAGDICTTSWQLSPVWQQMRL WTQARQMGWYAAKCMAAASSGDSID MDFSFELFAHVTKFFNYKVVLLGKY NAQGLGSDHELMLRCTKGREYIKVV MQNGRMMGAVLIGETDLEETFENLI LNQMNLSSYGEDLLDPNIDIEDYFD TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |