| Description : |
The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
163.7 kDa |
| AA Sequence : |
MRKDRLLHLCLVLLLILLSASDSNS TEPQYMVLVPSLLHTEAPKKGCVLL SHLNETVTVSASLESGRENRSLFTD LVAEKDLFHCVSFTLPRISASSEVA FLSIQIKGPTQDFRKRNTVLVLNTQ SLVFVQTDKPMYKPGQTVRFRVVSV DENFRPRNELIPLIYLENPRRNRIA QWQSLKLEAGINQLSFPLSSEPIQG SYRVVVQTESGGRIQHPFTVEEFVL PKFEVKVQVPKIISIMDEKVNITVC GEYTYGKPVPGLATVSLCRKLSRVL NCDKQEVCEEFSQQLNSNGCITQQV HTKMLQITNTGFEMKLRVEARIREE GTDLEVTANRISEITNIVSKLKFVK VDSHFRQGIPFFAQVLLVDGKGVPI PNKLFFISVNDANYYSNATTNEQGL AQFSINTTSISVNKLFVRVFTVHPN LCFHYSWVAEDHQGAQHTANRVFSL SGSYIHLEPVAGTLPCGHTETITAH YTLNRQAMGELSELSFHYLIMAKGV IVRSGTHTLPVESGDMKGSFALSFP VESDVAPIARMFIFAILPDGEVVGD SEKFEIENCLANKVDLSFSPAQSPP ASHAHLQVAAAPQSLCALRAVDQSV LLMKPEAELSVSSVYNLLTVKDLTN FPDNVDQQEEEQGHCPRPFFIHNGA IYVPLSSNEADIYSFLKGMGLKVFT NSKIRKPKSCSVIPSVSAGAVGQGY YGAGLGVVERPYVPQLGTYNVIPLN NEQSSGPVPETVRSYFPETWIWELV AVNSSGVAEVGVTVPDTITEWKAGA FCLSEDAGLGISSTASLRAFQPFFV ELTMPYSVIRGEVFTLKATVLNYLP KCIRVSVQLKASPAFLASQNTKGEE SYCICGNERQTLSWTVTPKTLGNVN FSVSAEAMQSLELCGNEVVEVPEIK RKDTVIKTLLVEAEGIEQEKTFSSM TCASGANVSEQLSLKLPSNVVKESA RASFSVLGDILGSAMQNIQNLLQMP YGCGEQNMVLFAPNIYVLNYLNETQ QLTQEIKAKAVGYLITGYQRQLNYK HQDGSYSTFGERYGRNQGNTWLTAF VLKTFAQARSYIFIDEAHITQSLTW LSQMQKDNGCFRSSGSLLNNAIKGG VEDEATLSAYVTIALLEIPLPVTNP IVRNALFCLESAWNVAKEGTHGSHV YTKALLAYAFSLLGKQNQNREILNS LDKEAVKEDNLVHWERPQRPKAPVG HLYQTQAPSAEVEMTSYVLLAYLTA QPAPTSGDLTSATNIVKWIMKQQNA QGGFSSTQDTVVALHALSRYGAATF TRTEKTAQVTVQDSQTFSTNFQVDN NNLLLLQQISLPELPGEYVITVTGE RCVYLQTSMKYNILPEKEDSPFALK VQTVPQTCDGHKAHTSFQISLTISY TGNRPASNMVIVDVKMVSGFIPLKP TVKMLERSSSVSRTEVSNNHVLIYV EQVTNQTLSFSFMVLQDIPVGDLKP AIVKVYDYYETDESVVAEYIAPCST DTEHGNVTRTRPLEQKLISEEDLAA NDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
