Recombinant Human RABGAP1L Protein, MYC/DDK-tagged, C13 and N15-labeled
Cat.No. : | RABGAP1L-134H |
Product Overview : | RABGAP1L MS Standard C13 and N15-labeled recombinant protein (NP_055672) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP. Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 92.3 kDa |
AA Sequence : | MEVRASLQKVSGSSDSVATMNSEEF VLVPQYADDNSTKHEEKPQLKIVSN GDEQLEKAMEEILRDSEKRPSSLLV DCQSSSEISDHSFGDIPASQTNKPS LQLILDPSNTEISTPRPSSPGGLPE EDSVLFNKLTYLGCMKVSSPRNEVE ALRAMATMKSSSQYPFPVTLYVPNV PEGSVRIIDQSSNVEIASFPIYKVL FCARGHDGTTESNCFAFTESSHGSE EFQIHVFSCEIKEAVSRILYSFCTA FKRSSRQVSDVKDSVIPTPDSDVFT FSVSLEVKEDDGKGNFSPVPKDRDK FYFKLKQGIEKKVVITVQQLSNKEL AIERCFGMLLSPGRNVKNSDMHLLD MESMGKSYDGRAYVITGMWNPNAPV FLALNEETPKDKQVYMTVAVDMVVT EVVEPVRFLLETVVRVYPANERFWY FSRKTFTETFFMRLKQSEGKGHTNA GDAIYEVVSLQRESDKEEPVTPTSG GGPMSPQDDEAEEESDNELSSGTGD VSKDCPEKILYSWGELLGKWHSNLG ARPKGLSTLVKSGVPEALRAEVWQL LAGCHDNQAMLDRYRILITKDSAQE SVITRDIHRTFPAHDYFKDTGGDGQ ESLYKICKAYSVYDEDIGYCQGQSF LAAVLLLHMPEEQAFCVLVKIMYDY GLRDLYRNNFEDLHCKFYQLERLMQ EQLPDLHSHFSDLNLEAHMYASQWF LTLFTAKFPLCMVFHIIDLLLCEGL NIIFHVALALLKTSKEDLLQADFEG ALKFFRVQLPKRYRAEENARRLMEQ ACNIKVPTKKLKKYEKEYQTMRESQ LQQEDPMDRYKFVYLTRTRPLEQKL ISEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | RABGAP1L RAB GTPase activating protein 1 like [ Homo sapiens (human) ] |
Official Symbol : | RABGAP1L |
Synonyms : | RABGAP1L; RAB GTPase activating protein 1 like; HHL; TBC1D18; rab GTPase-activating protein 1-like; TBC1 domain family, member 18; expressed in hematopoietic cells, heart, liver (HLL) |
Gene ID : | 9910 |
mRNA Refseq : | NM_014857 |
Protein Refseq : | NP_055672 |
MIM : | 609238 |
UniProt ID : | Q5R372 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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