Recombinant Human RAC1, GST-tagged
Cat.No. : | RAC1-7034H |
Product Overview : | Recombinant full-length human RAC1 was expressed in E. coli cells using an N-terminal GST tag. |
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Description : | RAC1 is a member of the Rho family and is a GTPase that is part of the small GTP-binding protein superfamily. RAC1 is involved in a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Role of RAC1 in colorectal cancer has been reported after analysis of the protein expression level and activities of this protein in matched sets of tumor and non-tumor tissues. Overexpression of RAC1 leads to increased tumour growth in xenografts of human colorectal tumour cells. RAC1 is also involved in the regulation of critical cellular functions including organization of actin cytoskeleton, transcription control and cell cycle. |
Source : | E. coli |
Species : | Human |
Tag : | GST |
Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Molecular Mass : | ~47 kDa |
Protein length : | Full length |
Purity : | >95% |
Applications : | Kinase Assay, Western Blot |
Storage : | Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.2 μg/μl |
Gene Name : | RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [ Homo sapiens ] |
Official Symbol : | RAC1 |
Synonyms : | RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); ras-related C3 botulinum toxin substrate 1; p21 Rac1; Rac 1; TC 25; ras-like protein TC25; cell migration-inducing gene 5 protein; MIG5; Rac-1; TC-25; p21-Rac1; MGC111543; |
Gene ID : | 5879 |
mRNA Refseq : | NM_006908 |
Protein Refseq : | NP_008839 |
MIM : | 602048 |
UniProt ID : | P63000 |
Chromosome Location : | 7p22 |
Pathway : | Activation of Rac, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; |
Function : | GTP binding; GTPase activity; enzyme binding; nucleotide binding; protein binding; thioesterase binding; |
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◆ Lysates | ||
RAC1-712HCL | Recombinant Human RAC1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, there are clinical trials investigating the efficacy of RAC1-targeted therapies in various diseases, including cancer and inflammatory disorders.
RAC1 activation is implicated in the development of diabetic complications, particularly in the context of vascular dysfunction and diabetic nephropathy.
Research suggests that altered RAC1 expression and activity may serve as a biomarker for certain neurodegenerative diseases.
RAC1 is crucial for neurite outgrowth and synaptic plasticity, and its dysregulation has been implicated in neurological disorders, suggesting a potential target for therapeutic interventions.
RAC1 is involved in vascular smooth muscle cell migration, and its dysregulation is associated with cardiovascular diseases. Targeting RAC1 may offer therapeutic benefits in such cases.
Customer Reviews (3)
Write a reviewRAC1 protein is highly recommended for researchers and scientists due to its exceptional performance in ELISA assays.
Its reliability in ELISA makes it a trusted tool for quantitative and qualitative protein analysis.
With its superior binding affinity and specificity, RAC1 protein enables accurate and reliable detection of target analytes in various biological samples.
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