Recombinant Human RAC1 protein, GST-tagged

• Cat.No.: RAC1-2213H
• Product Overview: Recombinant Human RAC1 protein(NP_008839.2)(Met1-Cys189), fused with GST tag, was expressed in Insect Cells.

Specification

• Source: Insect Cells
• Species: Human
• Tag: GST
• Form: Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Molecular Mass: The recombinant human RAC1/GST chimera consists of 414 amino acids and predicts a molecular mass of 47 kDa. It migrates as an approximately 44 kDa band in SDS-PAGE under reducing conditions.
• Protein Length: Met1-Cys189
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C
  Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [ Homo sapiens ]
• Official Symbol: RAC1
• Synonyms: RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); ras-related C3 botulinum toxin substrate 1; p21 Rac1; Rac 1; TC 25; ras-like protein TC25; cell migration-inducing gene 5 protein; MIG5; Rac-1; TC-25; p21-Rac1; MGC111543
• Gene ID: 5879
• mRNA Refseq: NM_006908
• Protein Refseq: NP_008839
• MIM: 602048
• UniProt ID: P63000

Reviews

05/03/2022

RAC1 protein is highly recommended for researchers and scientists due to its exceptional performance in ELISA assays.

12/20/2021

Its reliability in ELISA makes it a trusted tool for quantitative and qualitative protein analysis.

12/22/2018

With its superior binding affinity and specificity, RAC1 protein enables accurate and reliable detection of target analytes in various biological samples.

Q&As

Are there any ongoing clinical trials targeting RAC1 for therapeutic purposes?

Yes, there are clinical trials investigating the efficacy of RAC1-targeted therapies in various diseases, including cancer and inflammatory disorders.

How does RAC1 influence the progression of diabetic complications?

RAC1 activation is implicated in the development of diabetic complications, particularly in the context of vascular dysfunction and diabetic nephropathy.

Can RAC1 be a biomarker for neurodegenerative diseases?

Research suggests that altered RAC1 expression and activity may serve as a biomarker for certain neurodegenerative diseases.

In what ways does RAC1 impact neuronal function, and how does this relate to neurological disorders?

RAC1 is crucial for neurite outgrowth and synaptic plasticity, and its dysregulation has been implicated in neurological disorders, suggesting a potential target for therapeutic interventions.

How does RAC1 contribute to cardiovascular diseases, and what are the potential therapeutic interventions?

RAC1 is involved in vascular smooth muscle cell migration, and its dysregulation is associated with cardiovascular diseases. Targeting RAC1 may offer therapeutic benefits in such cases.