Recombinant Human RAC2 protein, His-tagged

• Cat.No.: RAC2-2549H
• Product Overview: Recombinant Human RAC2 protein(P15153)(Met1-Cys189), fused with His tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized from sterile PBS, 20% glycerol, pH 7.5Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Molecular Mass: The recombinant human RAC2 comprises 200 amino acids and has a predicted molecular mass of 22.6 kDa. It migrates as an approximately 25 kDa band in SDS-PAGE under reducing conditions.
• Protein Length: Met1-Cys189
• Purity: > 94 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C
  Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [ Homo sapiens ]
• Official Symbol: RAC2
• Synonyms: RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); ras-related C3 botulinum toxin substrate 2; EN 7; p21-Rac2; small G protein; rho family, small GTP binding protein Rac2; Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2); Gx; EN-7; HSPC022
• Gene ID: 5880
• mRNA Refseq: NM_002872
• Protein Refseq: NP_002863
• MIM: 602049
• UniProt ID: P15153

Reviews

09/17/2022

RAC2 protein has shown great utility in protein electron microscopy structure analysis.

08/10/2021

The use of RAC2 protein in such analyses provides valuable structural insights that contribute to the elucidation of ANO2's functional mechanisms and potential drug targeting sites.

12/05/2017

By visualizing the structural features, interactions, and conformational changes of RAC2, researchers gain valuable insights into its function and potential for therapeutic interventions.

Q&As

Are there any drugs targeting RAC2 for clinical use?

Several small molecule inhibitors targeting RAC2 are under development for the treatment of cancer and other diseases.

Can RAC2 inhibitors have potential side effects?

Like any targeted therapy, RAC2 inhibitors may have potential side effects, which need to be carefully evaluated in clinical trials.

How does RAC2 protein interact with other cellular proteins?

RAC2 interacts with various downstream effectors and signaling molecules to regulate cellular processes such as cytoskeletal dynamics and gene expression.

Are there any specific genetic disorders associated with RAC2 mutations?

Yes, mutations in the RAC2 gene have been linked to primary immunodeficiency disorders, affecting the function of immune cells.

Can RAC2 protein be used as a biomarker for disease diagnosis?

Yes, abnormal expression or activity of RAC2 has been observed in certain diseases, making it a potential biomarker for diagnostic purposes.