Recombinant Human RAPGEF3 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | RAPGEF3-3474H |
Product Overview : | RAPGEF3 MS Standard C13 and N15-labeled recombinant protein (NP_001092002) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
- Download
Description : | Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 99.2 kDa |
AA Sequence : | MVLRRMHRPRSCSYQLLLEHQRPSC IQGLRWTPLTNSEESLDFSESLEQA STERVLRAGRQLHRHLLATCPNLIR DRKYHLRLYRQCCSGRELVDGILAL GLGVHSRSQVVGICQVLLDEGALCH VKHDWAFQDRDAQFYRFPGPEPEPV GTHEMEEELAEAVALLSQRGPDALL TVALRKPPGQRTDEELDLIFEELLH IKAVAHLSNSVKRELAAVLLFEPHS KAGTVLFSQGDKGTSWYIIWKGSVN VVTHGKGLVTTLHEGDDFGQLALVN DAPRAATIILREDNCHFLRVDKQDF NRIIKDVEAKTMRLEEHGKVVLVLE RASQGAGPSRPPTPGRNRYTVMSGT PEKILELLLEAMGPDSSAHDPTETF LSDFLLTHRVFMPSAQLCAALLHHF HVEPAGGSEQERSTYVCNKRQQILR LVSQWVALYGSMLHTDPVATSFLQK LSDLVGRDTRLSNLLREQWPERRRC HRLENGCGNASPQMKARNLPVWLPN QDEPLPGSSCAIQVGDKVPYDICRP DHSVLTLQLPVTASVREVMAALAQE DGWTKGQVLVKVNSAGDAIGLQPDA RGVATSLGLNERLFVVNPQEVHELI PHPDQLGPTVGSAEGLDLVSAKDLA GQLTDHDWSLFNSIHQVELIHYVLG PQHLRDVTTANLERFMRRFNELQYW VATELCLCPVPGPRAQLLRKFIKLA AHLKEQKNLNSFFAVMFGLSNSAIS RLAHTWERLPHKVRKLYSALERLLD PSWNHRVYRLALAKLSPPVIPFMPL LLKDMTFIHEGNHTLVENLINFEKM RMMARAARMLHHCRSHNPVPLSPLR SRVSHLHEDSQVARISTCSEQSLST RSPASTWAYVQQLKVIDNQRELSRL SRELEPTRTRPLEQKLISEEDLAAN DILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | RAPGEF3 Rap guanine nucleotide exchange factor 3 [ Homo sapiens (human) ] |
Official Symbol : | RAPGEF3 |
Synonyms : | RAPGEF3; Rap guanine nucleotide exchange factor (GEF) 3; RAP guanine nucleotide exchange factor (GEF) 3; rap guanine nucleotide exchange factor 3; bcm910; cAMP GEFI; EPAC; exchange protein directly activated by cAMP 1; EPAC 1; 9330170P05Rik; exchange factor directly activated by cAMP 1; cAMP-regulated guanine nucleotide exchange factor I; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; EPAC1; HSU79275; CAMP-GEFI; MGC21410; |
Gene ID : | 10411 |
mRNA Refseq : | NM_001098532 |
Protein Refseq : | NP_001092002 |
MIM : | 606057 |
UniProt ID : | O95398 |
Products Types
◆ Recombinant Protein | ||
Rapgef3-5377M | Recombinant Mouse Rapgef3 Protein, Myc/DDK-tagged | +Inquiry |
RAPGEF3-4586R | Recombinant Rat RAPGEF3 Protein, His (Fc)-Avi-tagged | +Inquiry |
RAPGEF3-135H | Recombinant Human RAPGEF3, MYC/DDK-tagged | +Inquiry |
RAPGEF3-3056H | Recombinant Human RAPGEF3 protein, His-tagged | +Inquiry |
RAPGEF3-2181H | Recombinant Human RAPGEF3, GST-tagged | +Inquiry |
◆ Lysates | ||
RAPGEF3-2521HCL | Recombinant Human RAPGEF3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (0)
Ask a questionAsk a Question for All RAPGEF3 Products
Required fields are marked with *
My Review for All RAPGEF3 Products
Required fields are marked with *
0
Inquiry Basket