Recombinant Human Ras-related C3 Botulinum Toxin Substrate 2 (Rho Family, Small GTP Binding Protein Rac2), GST-tagged
Cat.No. : | RAC2-343H |
Product Overview : | Recombinant GST tagged RAC2 was expressed in E.coli and purified by using conventional chromatography techniques (419 aa, 47 kDa). |
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Cat. No. : | RAC2-343H |
Description : | Rac2 is a small signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. Rac proteins play important roles in multiple cellular events, including actin cytoskeletal organization, cell proliferation and survival, cell cycle progression, and gene transcription regulation. |
Source : | E.coli. |
Formulation : | Liquid. In Phosphate Buffered Saline( pH 7.4). |
Molecular Weight : | 47 kDa (419 aa). |
Purity : | > 90% by SDS – PAGE. |
Concentration : | 1 mg/ml (determined by Bradford assay). |
Sequence : | MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD LVPRGSHMQA IKCVVVGDGA VGKTCLLISY TTNAFPGEYI PTVFDNYSAN VMVDSKPVNL GLWDTAGQED YDRLRPLSYP QTDVFLICFS LVSPASYENV RAKWFPEVRH HCPSTPIILV GTKLDLRDDK DTIEKLKEKK LAPITYPQGL ALAKEIDSVK YLECSALTQR GLKTVFDEAI RAVLCPQPTR QQKRACSLL |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | RAC2 |
Synonyms : | RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); Gx; EN-7; HSPC022; GX; p21-Rac2; Small G protein; ras-related C3 botulinum toxin substrate 2; rho family, small GTP binding protein Rac2; RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2). |
Gene ID : | 5880 |
mRNA Refseq : | NM_002872.3 |
Protein Refseq : | NP_002863.1 |
MIM : | 602049 |
UniProt ID : | P15153 |
Chromosome Location : | 22q13.1 |
Pathway : | Adherens junction; Axon guidance; B cell receptor signaling pathway; Colorectal cancer; Fc epsilon RI signaling pathway; Focal adhesion; Leukocyte transendothelial migration; MAPK signaling pathway; Natural killer cell mediated cytotoxicity; Pancreatic cancer; Regulation of actin cytoskeleton; VEGF signaling pathway; Wnt signaling pathway; Signaling by Rho GTPases. |
Function : | GTP binding; GTPase activity; nucleotide binding; protein binding. |
Products Types
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionSeveral small molecule inhibitors targeting RAC2 are under development for the treatment of cancer and other diseases.
Like any targeted therapy, RAC2 inhibitors may have potential side effects, which need to be carefully evaluated in clinical trials.
RAC2 interacts with various downstream effectors and signaling molecules to regulate cellular processes such as cytoskeletal dynamics and gene expression.
Yes, mutations in the RAC2 gene have been linked to primary immunodeficiency disorders, affecting the function of immune cells.
Yes, abnormal expression or activity of RAC2 has been observed in certain diseases, making it a potential biomarker for diagnostic purposes.
Customer Reviews (3)
Write a reviewRAC2 protein has shown great utility in protein electron microscopy structure analysis.
The use of RAC2 protein in such analyses provides valuable structural insights that contribute to the elucidation of ANO2's functional mechanisms and potential drug targeting sites.
By visualizing the structural features, interactions, and conformational changes of RAC2, researchers gain valuable insights into its function and potential for therapeutic interventions.
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