Recombinant Human RASGRF1 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | RASGRF1-2036H |
Product Overview : | RASGRF1 MS Standard C13 and N15-labeled recombinant protein (NP_002882) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 145.1 kDa |
AA Sequence : | MQKGIRLNDGHVASLGLLARKDGTR KGYLSKRSSDNTKWQTKWFALLQNL LFYFESDSSSRPSGLYLLEGCVCDR APSPKPALSAKEPLEKQHYFTVNFS HENQKALELRTEDAKDCDEWVAAIA HASYRTLATEHEALMQKYLHLLQIV ETEKTVAKQLRQQIEDGEIEIERLK AEITSLLKDNERIQSTQTVAPNDED SDIKKIKKVQSFLRGWLCRRKWKTI IQDYIRSPHADSMRKRNQVVFSMLE AEAEYVQQLHILVNNFLRPLRMAAS SKKPPITHDDVSSIFLNSETIMFLH QIFYQGLKARISSWPTLVLADLFDI LLPMLNIYQEFVRNHQYSLQILAHC KQNRDFDKLLKHYEAKPDCEERTLE TFLTYPMFQIPRYILTLHELLAHTP HEHVERNSLDYAKSKLEELSRIMHD EVSETENIRKNLAIERMIIEGCEIL LDTSQTFVRQGSLIQVPMSEKGKIT RGRLGSLSLKKEGERQCFLFSKHLI ICTRGSGGKLHLTKNGVISLIDCTL LEEPESTEEEAKGSGQDIDHLDFKI GVEPKDSPPFTVILVASSRQEKAAW TSDISQCVDNIRCNGLMMNAFEENS KVTVPQMIKRTREGTREAEMSRSDA SLYCDDVDIRFSKTMNSCKVLQIRY ASVERLLERLTDLRFLSIDFLNTFL HSYRVFTTAIVVLDKLITIYKKPIS AIPARWLRSLELLFASGQNNKLLYG EPPKSPRATRKFSSPPPLSITKTSS PSRRRKLSLNIPIITGGKALDLAAL SCNSNGYTSMYSAMSPFSKATLDTS KLYVSSSFTNKIPDEGDTTPEKPED PSALSKQSSEVSMREESDIDQNQSD DGDTETSPTKSPTTPKSVKNKNSSE FPLFSYNNGVVMTSCRELDNNRSAL SAASAFAIATAGANEGTPNKEKYRR MSLASAGFPPDQRNGDKEFVIRRAA TNRVLNVLRHWVSKHSQDFETNDEL KCKVIGFLEEVMHDPELLTQERKAA ANIIRTLTQEDPGDNQITLEEITQM AEGVKAEPFENHSALEIAEQLTLLD HLVFKKIPYEEFFGQGWMKLEKNER TPYIMKTTKHFNDISNLIASEIIRN EDINARVSAIEKWVAVADICRCLHN YNAVLEITSSMNRSAIFRLKKTWLK VSKQTKALIDKLQKLVSSEGRFKNL REALKNCDPPCVPYLGMYLTDLAFI EEGTPNYTEDGLVNFSKMRMISHII REIRQFQQTAYKIEHQAKVTQYLLD QSFVMDEESLYESSLRIEPKLPTTR TRPLEQKLISEEDLAANDILDYKDD DDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 [ Homo sapiens (human) ] |
Official Symbol : | RASGRF1 |
Synonyms : | RASGRF1; Ras protein-specific guanine nucleotide-releasing factor 1; GRF1; ras-specific guanine nucleotide-releasing factor 1; CDC25; CDC25L; GNRP; GRF55; H GRF55; PP13187; guanine nucleotide exchange factor; guanine nucleotide-releasing protein; guanine nucleotide-releasing factor 1; guanine nucleotide-releasing factor, 55 kD; Ras-specific nucleotide exchange factor CDC25; Ras-specific guanine nucleotide-releasing factor, CDC25 homolog; H-GRF55; ras-GRF1; |
Gene ID : | 5923 |
mRNA Refseq : | NM_002891 |
Protein Refseq : | NP_002882 |
MIM : | 606600 |
UniProt ID : | Q13972 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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