Recombinant Human RASGRF2 Protein, His-tagged

• Cat.No.: RASGRF2-01H
• Product Overview: Recombinant Human RASGRF2 protein(NP_008840.1), fused to His-tag, was expressed in E. coli.

Specification

• Description: RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways.
• Source: E. coli
• Species: Human
• Tag: His
• Form: PBS buffer
• Molecular Mass: The protein has a calculated MW of 72 kDa.
• AA Sequence: MHHHHHHHHMIKSDARLHKDDTDIC FSKTLNSCKVPQIRYASVERLLERL TDLRFLSIDFLNTFLHTYRIFTTAA VVLGKLSDIYKRPFTSIPVRSLELF FATSQNNRGEHLVDGKSPRLCRKFS SPPPLAVSRTSSPVRARKLSLTSPL NSKIGALDLTTSSSPTTTTQSPAAS PPPHTGQIPLDLSRGLSSPEQSPGT VEENVDNPRVDLCNKLKRSIQKAVL ESAPADRAGVESSPAADTTELSPCR SPSTPRHLRYRQPGGQTADNAHCSV SPASAFAIATAAAGHGSPPGFNNTE RTCDKEFIIRRTATNRVLNVLRHWV SKHAQDFELNNELKMNVLNLLEEVL RDPDLLPQERKAAANILRALSQDDQ DDIHLKLEDIIQMTDCMKAECFESL SAMELAEQITLLDHVIFRSIPYEEF LGQGWMKLDKNERTPYIMKTSQHFN DMSNLVASQIMNYADVSSRANAIEK WVAVADICRCLHNYNGVLEITSALN RSAIYRLKKTWAKVSKQTKALMDKL QKTVSSEGRFKNLRETLKNCNPPAV PYLGMYLTDLAFIEEGTPNFTEEGL VNFSKMRMISHIIREIRQFQQTSYR IDHQPKVAQYLLDKDLIIDEDTLYE LSLKIEPRLPA
• Purity: > 95% by SDS-PAGE
• Storage: Store it under sterile conditions at -20 to -80 ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 0.2 mg/ml

Gene Information

• Gene Name: RASGRF2 Ras protein specific guanine nucleotide releasing factor 2 [ Homo sapiens (human) ]
• Official Symbol: RASGRF2
• Synonyms: GRF2; RAS-GRF2
• Gene ID: 5924
• mRNA Refseq: NM_006909.3
• Protein Refseq: NP_008840.1
• MIM: 606614
• UniProt ID: O14827