Recombinant Human RASGRP1 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | RASGRP1-1166H |
Product Overview : | RASGRP1 MS Standard C13 and N15-labeled recombinant protein (NP_005730) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 90.4 kDa |
AA Sequence : | MGTLGKAREAPRKPSHGCRAASKAR LEAKPANSPFPSHPSLAHITQFRMM VSLGHLAKGASLDDLIDSCIQSFDA DGNLCRSNQLLQVMLTMHRIVISSA ELLQKVITLYKDALAKNSPGLCLKI CYFVRYWITEFWVMFKMDASLTDTM EEFQELVKAKGEELHCRLIDTTQIN ARDWSRKLTQRIKSNTSKKRKVSLL FDHLEPEELSEHLTYLEFKSFRRIS FSDYQNYLVNSCVKENPTMERSIAL CNGISQWVQLMVLSRPTPQLRAEVF IKFIQVAQKLHQLQNFNTLMAVIGG LCHSSISRLKETSSHVPHEINKVLG EMTELLSSSRNYDNYRRAYGECTDF KIPILGVHLKDLISLYEAMPDYLED GKVNVHKLLALYNHISELVQLQEVA PPLEANKDLVHLLTLSLDLYYTEDE IYELSYAREPRNHRAPPLTPSKPPV VVDWASGVSPKPDPKTISKHVQRMV DSVFKNYDHDQDGYISQEEFEKIAA SFPFSFCVMDKDREGLISRDEITAY FMRASSIYSKLGLGFPHNFQETTYL KPTFCDNCAGFLWGVIKQGYRCKDC GMNCHKQCKDLVVFECKKRAKNPVA PTENNTSVGPVSNLCSLGAKDLLHA PEEGPFTFPNGEAVEHGEESKDRTI MLMGVSSQKISLRLKRAVAHKATQT ESQPWIGSEGPSGPFVLSSPRKTAQ DTLYVLPSPTSPCPSPVLVRKRAFV KWENKDSLIKSKEELRHLRLPTYQE LEQEINTLKADNDALKIQLKYAQKK IESLQLEKSNHVLAQMEQGDCSTRT RPLEQKLISEEDLAANDILDYKDDD DKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | RASGRP1 RAS guanyl releasing protein 1 [ Homo sapiens (human) ] |
Official Symbol : | RASGRP1 |
Synonyms : | RASGRP1; RAS guanyl releasing protein 1 (calcium and DAG-regulated); RAS guanyl-releasing protein 1; CalDAG GEFII; RASGRP; ras activator RasGRP; RAS guanyl nucleotide-releasing protein 1; calcium and DAG-regulated guanine nucleotide exchange factor II; guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A; V; hRasGRP1; CALDAG-GEFI; CALDAG-GEFII; MGC129998; MGC129999; |
Gene ID : | 10125 |
mRNA Refseq : | NM_005739 |
Protein Refseq : | NP_005730 |
MIM : | 603962 |
UniProt ID : | O95267 |
Products Types
◆ Recombinant Protein | ||
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Rasgrp1-5389M | Recombinant Mouse Rasgrp1 Protein, Myc/DDK-tagged | +Inquiry |
RASGRP1-13953M | Recombinant Mouse RASGRP1 Protein | +Inquiry |
◆ Lysates | ||
RASGRP1-2506HCL | Recombinant Human RASGRP1 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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