Recombinant Human RB1, GST-tagged
Cat.No. : | RB1-570H |
Product Overview : | Recombinant Human RB1, fused with N-terminal GST tag, was expressed in an E. coli expression system. |
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Description : | The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. |
Source : | E. coli |
Species : | Human |
Tag : | GST |
Form : | 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 18 mM Glutathione, 10% glycerol, and 3 mM DTT. |
Molecular Mass : | 43.5 kDa |
Purity : | ≥ 47% |
Applications : | Kinase substrate for the kinase assay; western blot |
Storage : | >6 months at –80°C |
Gene Name : | RB1 retinoblastoma 1 [ Homo sapiens ] |
Official Symbol : | RB1 |
Synonyms : | RB1; retinoblastoma 1; RB; pRb; OSRC; pp110; p105-Rb; RB1; osteosarcoma; OTTHUMP00000018397; Rb; retinoblastoma suspectibility protein; retinoblastoma-associated protein |
Gene ID : | 5925 |
mRNA Refseq : | NM_000321 |
Protein Refseq : | NP_000312 |
MIM : | 180200 |
UniProt ID : | P06400 |
Chromosome Location : | 13q14.2 |
Pathway : | Bladder cancer; Cell cycle; Chronic myeloid leukemia; Glioma; Melanoma; Non-small cell lung cancer; Pancreatic cancer; |
Function : | androgen receptor binding; kinase binding; phosphoprotein binding; transcription coactivator activity; transcription factor activity; transcription factor binding; transcription repressor activity; ubiquitin protein ligase binding |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionMutations in RB1 lead to retinoblastoma and increase the risk of other cancers, disrupting normal cell cycle control.
RB1 interacts with transcription factors to regulate gene expression, impacting various cellular processes.
RB1 plays a crucial role in the DNA damage response, facilitating repair and maintaining genomic stability.
RB1 controls the G1 to S phase transition in the cell cycle, preventing unregulated cell division.
Changes in RB1 function affect stem cell differentiation and tissue regeneration, influencing tissue maintenance and repair.
RB1 influences cellular senescence and apoptosis, playing a role in aging and cell turnover.
As a tumor suppressor, RB1 prevents excessive cell proliferation and contributes to cancer prevention.
Customer Reviews (3)
Write a reviewEfficient protein purification, delivers consistent yield and purity.
Expertise in protein engineering, a trusted resource for research.
Reliable protein crystallization services, exceptional results achieved.
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