Recombinant Human RB1 protein, His-tagged
Cat.No. : | RB1-0401H |
Product Overview : | Recombinant Human RB1 protein(576-928 aa), fused to His tag, was expressed in E. coli. |
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Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH7.4). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 300mM imidazole. |
Protein length : | 576-928 aa |
AA Sequence : | SKDREGPTDHLESACPLNLPLQNNH TAADMYLSPVRSPKKKGSTTRVNST ANAETQATSAFQTQKPLKSTSLSLF YKKVYRLAYLRLNTLCERLLSEHPE LEHIIWTLFQHTLQNEYELMRDRHL DQIMMCSMYGICKVKNIDLKFKIIV TAYKDLPHAVQETFKRVLIKEEEYD SIIVFYNSVFMQRLKTNILQYASTR PPTLSPIPHIPRSPYKFPSSPLRIP GGNIYISPLKSPYKISEGLPTPTKM TPRSRILVSIGESFGTSEKFQKINQ MVCNSDRVLKRSAEGSNPPKPLKKL RFDIEGSDEADGSKHLPGESKFQQK LAEMTSTRTRMQKQKMNDSMDTSNK EEK |
Purity : | 85%, by SDS-PAGE with Coomassie Brilliant Blue staining. |
Storage : | Short-term storage: Store at 2-8°C for (1-2 weeks). Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles. |
Reconstitution : | Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage. Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage. |
Gene Name : | RB1 retinoblastoma 1 [ Homo sapiens ] |
Official Symbol : | RB1 |
Synonyms : | RB1; retinoblastoma 1; OSRC, osteosarcoma; retinoblastoma-associated protein; RB; retinoblastoma suspectibility protein; pRb; OSRC; pp110; p105-Rb; |
Gene ID : | 5925 |
mRNA Refseq : | NM_000321 |
Protein Refseq : | NP_000312 |
MIM : | 614041 |
UniProt ID : | P06400 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionMutations in RB1 lead to retinoblastoma and increase the risk of other cancers, disrupting normal cell cycle control.
RB1 interacts with transcription factors to regulate gene expression, impacting various cellular processes.
RB1 plays a crucial role in the DNA damage response, facilitating repair and maintaining genomic stability.
RB1 controls the G1 to S phase transition in the cell cycle, preventing unregulated cell division.
Changes in RB1 function affect stem cell differentiation and tissue regeneration, influencing tissue maintenance and repair.
RB1 influences cellular senescence and apoptosis, playing a role in aging and cell turnover.
As a tumor suppressor, RB1 prevents excessive cell proliferation and contributes to cancer prevention.
Customer Reviews (3)
Write a reviewEfficient protein purification, delivers consistent yield and purity.
Expertise in protein engineering, a trusted resource for research.
Reliable protein crystallization services, exceptional results achieved.
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