Recombinant Human RBBP4 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: RBBP4-6445H
• Product Overview: RBBP4 MS Standard C13 and N15-labeled recombinant protein (NP_005601) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 47.7 kDa
• AA Sequence: MADKEAAFDDAVEERVINEEYKIWK KNTPFLYDLVMTHALEWPSLTAQWL PDVTRPEGKDFSIHRLVLGTHTSDE QNHLVIASVQLPNDDAQFDASHYDS EKGEFGGFGSVSGKIEIEIKINHEG EVNRARYMPQNPCIIATKTPSSDVL VFDYTKHPSKPDPSGECNPDLRLRG HQKEGYGLSWNPNLSGHLLSASDDH TICLWDISAVPKEGKVVDAKTIFTG HTAVVEDVSWHLLHESLFGSVADDQ KLMIWDTRSNNTSKPSHSVDAHTAE VNCLSFNPYSEFILATGSADKTVAL WDLRNLKLKLHSFESHKDEIFQVQW SPHNETILASSGTDRRLNVWDLSKI GEEQSPEDAEDGPPELLFIHGGHTA KISDFSWNPNEPWVICSVSEDNIMQ VWQMAENIYNDEDPEGSVDPEGQGS TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: RBBP4 retinoblastoma binding protein 4 [ Homo sapiens (human) ]
• Official Symbol: RBBP4
• Synonyms: RBBP4; retinoblastoma binding protein 4; histone-binding protein RBBP4; NURF55; RbAp48; RBBP-4; CAF-I p48; CAF-1 subunit C; CAF-I 48 kDa subunit; MSI1 protein homolog; retinoblastoma-binding protein 4; retinoblastoma-binding protein p48; chromatin assembly factor 1 subunit C; chromatin assembly factor I p48 subunit; chromatin assembly factor/CAF-1 p48 subunit; nucleosome-remodeling factor subunit RBAP48; RBAP48
• Gene ID: 5928
• mRNA Refseq: NM_005610
• Protein Refseq: NP_005601
• MIM: 602923
• UniProt ID: Q09028

Reviews

12/20/2020

They can offer specialized formulations, concentrations, or modifications of RBBP4 protein to suit unique experimental requirements.

04/19/2018

The manufacturer can further support researchers by providing customized solutions tailored to their specific needs.

06/20/2016

Collaborative discussions with the manufacturer can also help optimize experimental protocols and provide insights into the best practices in working with RBBP4.

Q&As

How is RBBP4 involved in cell differentiation?

RBBP4 participates in the regulation of genes involved in cell differentiation, which is crucial for the development and maintenance of tissues.

Are there any clinical applications for RBBP4 in cancer treatment?

Research into targeting RBBP4 in cancer therapy is ongoing, as it may help in developing novel treatments for certain types of cancer.

How can RBBP4 influence cancer progression?

RBBP4's role in gene regulation can impact the expression of genes involved in cell proliferation and differentiation, affecting cancer progression.

Can RBBP4 be used as a diagnostic marker for cancer?

RBBP4 is not typically used as a standalone diagnostic marker, but its expression levels can be studied to understand the molecular mechanisms underlying cancer.

What other diseases or conditions are associated with RBBP4?

RBBP4's role in gene regulation implicates it in various diseases and conditions beyond cancer, including neurological disorders and developmental diseases.