Recombinant Human RBL2 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | RBL2-881H |
Product Overview : | RBL2 MS Standard C13 and N15-labeled recombinant protein (NP_005602) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 128.3 kDa |
AA Sequence : | MPSGGDQSPPPPPPPPAAAASDEEE EDDGEAEDAAPPAESPTPQIQQRFD ELCSRLNMDEAARAEAWDSYRSMSE SYTLEGNDLHWLACALYVACRKSVP TVSKGTVEGNYVSLTRILKCSEQSL IEFFNKMKKWEDMANLPPHFRERTE RLERNFTVSAVIFKKYEPIFQDIFK YPQEEQPRQQRGRKQRRQPCTVSEI FHFCWVLFIYAKGNFPMISDDLVNS YHLLLCALDLVYGNALQCSNRKELV NPNFKGLSEDFHAKDSKPSSDPPCI IEKLCSLHDGLVLEAKGIKEHFWKP YIRKLYEKKLLKGKEENLTGFLEPG NFGESFKAINKAYEEYVLSVGNLDE RIFLGEDAEEEIGTLSRCLNAGSGT ETAERVQMKNILQQHFDKSKALRIS TPLTGVRYIKENSPCVTPVSTATHS LSRLHTMLTGLRNAPSEKLEQILRT CSRDPTQAIANRLKEMFEIYSQHFQ PDEDFSNCAKEIASKHFRFAEMLYY KVLESVIEQEQKRLGDMDLSGILEQ DAFHRSLLACCLEVVTFSYKPPGNF PFITEIFDVPLYHFYKVIEVFIRAE DGLCREVVKHLNQIEEQILDHLAWK PESPLWEKIRDNENRVPTCEEVMPP QNLERADEICIAGSPLTPRRVTEVR ADTGGLGRSITSPTTLYDRYSSPPA STTRRRLFVENDSPSDGGTPGRMPP QPLVNAVPVQNVSGETVSVTPVPGQ TLVTMATATVTANNGQTVTIPVQGI ANENGGITFFPVQVNVGGQAQAVTG SIQPLSAQALAGSLSSQQVTGTTLQ VPGQVAIQQISPGGQQQKQGQSVTS SSNRPRKTSSLSLFFRKVYHLAAVR LRDLCAKLDISDELRKKIWTCFEFS IIQCPELMMDRHLDQLLMCAIYVMA KVTKEDKSFQNIMRCYRTQPQARSQ VYRSVLIKGKRKRRNSGSSDSRSHQ NSPTELNKDRTSRDSSPVMRSSSTL PVPQPSSAPPTPTRLTGANSDMEEE ERGDLIQFYNNIYIKQIKTFAMKYS QANMDAPPLSPYPFVRTGSPRRIQL SQNHPVYISPHKNETMLSPREKIFY YFSNSPSKRLREINSMIHTGETPTK KRGILLEDGSESPAKRICPENHSAL LRRLQDVANDRGSHTRTRPLEQKLI SEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | RBL2 RB transcriptional corepressor like 2 [ Homo sapiens (human) ] |
Official Symbol : | RBL2 |
Synonyms : | RBL2; retinoblastoma-like 2 (p130); retinoblastoma-like protein 2; p130; Rb2; PRB2; RBR-2; retinoblastoma-related protein 2; 130 kDa retinoblastoma-associated protein; P130; FLJ26459; |
Gene ID : | 5934 |
mRNA Refseq : | NM_005611 |
Protein Refseq : | NP_005602 |
MIM : | 180203 |
UniProt ID : | Q08999 |
Products Types
◆ Recombinant Protein | ||
Rbl2-5409M | Recombinant Mouse Rbl2 Protein, Myc/DDK-tagged | +Inquiry |
RBL2-4614R | Recombinant Rat RBL2 Protein, His (Fc)-Avi-tagged | +Inquiry |
RBL2-4358H | Recombinant Human RBL2 protein, His-tagged | +Inquiry |
RBL2-2483H | Recombinant Human RBL2 protein, MYC/DDK-tagged | +Inquiry |
RBL2-2984C | Recombinant Chicken RBL2 | +Inquiry |
◆ Lysates | ||
RBL2-2483HCL | Recombinant Human RBL2 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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