Recombinant Human RBM25 protein, GST-tagged
Cat.No. : | RBM25-2212H |
Product Overview : | Recombinant RBM25 protein, fused to GST-tag, was expressed in E.coli. |
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Description : | RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Form : | The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.). 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
Molecular Mass : | 52 kDa |
Protein length : | 235 |
AA Sequence : | LKPTLRPISSAPSVSSASGNATPNT PGDESPCGIIIPHENSPDQQQPEEH RPKIGLSLKLGASNSPGQPNSVKRK KLPVDSVFNKFEDEDSDDVPRKRKL VPLDYGEDDKNATKGTVNTEEKRKH IKSLIEKIPTAKPELFAYPLDWSIV DSILMERRIRPWINKKIIEYIGEEE ATLVDFVCSKVMAHSSPQSILDDVA MVLDEEAEVFIVKMWRLLIYETEAK KIGLVK |
Purity : | 95%, by SDS-PAGE with Coomassie Brilliant Blue staining. |
Storage : | Short-term storage: Store at 2-8 centigrade for (1-2 weeks). Long-term storage: Aliquot and store at -20 centigrade to -80 centigrade for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles. |
Reconstitution : | Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage. Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage. If a different concentration is needed for your purposes please adjust the reconstitution volume as required (please note: the ion concentration of the final solution will vary according to the volume used). |
Gene Name : | RBM25 |
Official Symbol : | RBM25 |
Synonyms : | S164; NET52; RNPC7; Snu71; RED120; fSAP94 |
Gene ID : | 58517 |
mRNA Refseq : | NM_021239.3 |
Protein Refseq : | NP_067062.1 |
MIM : | 612427 |
UniProt ID : | P49756 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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