Recombinant Human RCVRN Protein (2-200 aa), His-tagged

• Cat.No.: RCVRN-1847H
• Product Overview: Recombinant Human RCVRN Protein (2-200 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Neuroscience. Protein Description: Full Length of Mature Protein.

Specification

• Description: Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse.
• Source: Yeast
• Species: Human
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 25.0 kDa
• Protein length: 2-200 aa
• AA Sequence: GNSKSGALSKEILEELQLNTKFSEE ELCSWYQSFLKDCPTGRITQQQFQS IYAKFFPDTDPKAYAQHVFRSFDSN LDGTLDFKEYVIALHMTTAGKTNQK LEWAFSLYDVDGNGTISKNEVLEIV MAIFKMITPEDVKLLPDDENTPEKR AEKIWKYFGKNDDDKLTEKEFIEGT LANKEILRLIQFEPQKVKEKMKNA
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: RCVRN recoverin [ Homo sapiens ]
• Official Symbol: RCVRN
• Synonyms: RCVRN; recoverin; RCV1; cancer associated retinopathy antigen
• Gene ID: 5957
• mRNA Refseq: NM_002903
• Protein Refseq: NP_002894
• MIM: 179618
• UniProt ID: P35243

Reviews

02/16/2020

Whether investigating metabolic pathways, studying enzymatic activity, or exploring drug targets, this protein offers versatility and reliability, allowing for accurate and meaningful data collection.

05/29/2018

In addition to the remarkable protein quality, the manufacturer provides excellent technical support, proving to be a valuable resource when troubleshooting experimental challenges.

06/24/2016

Incorporating this protein into scientific investigations undoubtedly enhances the reliability and effectiveness of research endeavors.

Q&As

Are there any specific populations that may benefit more from RCVRN-targeted therapies?

Individuals with genetic mutations affecting RCVRN and those with early-stage retinal diseases may potentially benefit more from targeted therapies.

How does the expression of RCVRN change with age, and does this have implications for age-related vision disorders?

The expression of RCVRN may change with age, and understanding these changes can provide insights into age-related vision disorders.

How is the level of RCVRN expression correlated with the progression of certain retinal disorders?

Changes in RCVRN expression levels may correlate with the progression of retinal disorders, serving as a potential indicator of disease severity.

Are there ongoing clinical trials exploring the use of RCVRN-based therapies?

Some clinical trials are investigating the safety and efficacy of gene therapies targeting the RCVRN gene for treating specific eye conditions.

How might the manipulation of RCVRN expression offer therapeutic benefits for patients with vision impairments?

Modulating RCVRN expression could potentially restore or enhance photoreceptor function, providing therapeutic benefits for vision-impaired individuals.