Recombinant Human REG3A protein(Met1-Asp175), His-tagged

• Cat.No.: REG3A-2337H
• Product Overview: Recombinant Human REG3A (Q06141-1) (Met 1-Asp 175) was expressed in HEK293, fused with a polyhistidine tag at the C-terminus.

Specification

• Source: HEK293
• Species: Human
• Tag: C-His
• Protein length: Met1-Asp175
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Molecular Mass: The recombinant human REG3A consists of 160 amino acids after removal of the signal peptide and has a predicted molecular mass of 18 kDa as estimated in SDS-PAGE under reducing conditions.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: > 97 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: REG3A regenerating islet-derived 3 alpha [ Homo sapiens ]
• Official Symbol: REG3A
• Synonyms: REG3A; regenerating islet-derived 3 alpha; pancreatitis associated protein , PAP; regenerating islet-derived protein 3-alpha; HIP; PAP1; PBCGF; REG III; REG3; REG-3-alpha; reg III-alpha; PAP homologous protein; human proislet peptide; pancreatitis-associated protein 1; proliferation-inducing protein 34; proliferation-inducing protein 42; hepatocarcinoma-intestine-pancreas; pancreatic beta cell growth factor; regenerating islet-derived protein III-alpha; PAP; PAP-H; REG-III; FLJ18565
• Gene ID: 5068
• mRNA Refseq: NM_002580
• Protein Refseq: NP_002571
• MIM: 167805
• UniProt ID: Q06141

Reviews

02/01/2022

REG3A protein is of exceptional quality and is highly recommended for meeting experimental needs.

12/16/2020

Its purity and integrity ensure reliable and reproducible results in a wide range of applications.

11/01/2017

the manufacturer of REG3A protein provides excellent technical support, ensuring prompt assistance and guidance.

Q&As

In what gastrointestinal disorders is REG3A protein implicated?

REG3A has been associated with inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, where its dysregulation can contribute to inflammation and tissue damage.

In what way does REG3A impact the microbiota of the gastrointestinal tract?

REG3A plays a role in maintaining the balance of the gut microbiota by influencing the composition of the microbial community.

Can REG3A be used as a biomarker for certain diseases?

Yes, altered levels of REG3A have been observed in several diseases, making it a potential biomarker for gastrointestinal disorders and certain cancers.

How does REG3A function in the context of the immune response?

REG3A has immunomodulatory effects, participating in the regulation of the immune response, particularly in the defense against bacterial infections.

How is REG3A being explored in cancer research?

REG3A's involvement in cell growth and differentiation has led to investigations into its role in cancer, with studies exploring its potential as a therapeutic target or diagnostic marker.