Recombinant Human REG4, His-tagged
Cat.No. : | REG4-194H |
Product Overview : | Recombinant Human regenerating islet-derived family, member 4 (His-tagged) contains 136 amino acids and has a molecular mass of 17.4 kDa. And this protein expressed inE.Coli. |
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Cat. No. : | REG4-194H |
Description : | REG protein was shown to be stimulated during the regeneration of pancreatic islets. Since then, many Reg-related proteins have been identified in humans and other animals. In human, the four REG family genes, i.e., REG 1 alpha, REG 1 beta, REG-related sequence (RS) and HIP/PAP, have so far been isolated. These Reg-related proteins are classified into four subfamilies according to their amino-acid sequences, but they share a similar structure and physiological function. Reg protein is a growth factor for pancreatic beta cells and also suggest that the administration of Reg protein could be used as another therapeutic approach for diabetes mellitus. human REG cDNA which encoded a 166-amino acid protein with a 22-amino acid signal peptide. The amino acid sequence of human REG protein has 68% homology to that of rat Reg protein. Reg I was found to be expressed mainly in pancreatic beta and acinoductular cells as well as gastric fundic enterochromaffin-like (ECL) cells. Reg I production in ECL cells is stimulated by gastrin, as well as by the proinflammatory cytokine, cytokine-induced neutrophil chemoattractant (CINC)-2Beta. |
Source : | E.Coli. |
Sequences Of Amino Acids : | MKHHHHHHAS HMDIIMRPSC APGWFYHKSN CYGYFRKLRN WSDAELECQS YGNGAHLASI LSLKEASTIA EYISGYQRSQ PIWIGLHDPQ KRQQWQWIDG AMYLYRSWSG KSMGGNKHC AEMSSNNNFLT WSSNECNKRQ HFLCKYRP. |
Specificity : | The amino acid sequence of the recombinant Human REG IV is 100% homologous to the amino acid sequence of the Human REG IV without signal sequence. |
Purification Method : | Ni-NTA chromatography. |
Purity : | >95% (SDS-PAGE analyzed). |
Formulation : | Sterile filtered and lyophilized from 0.5 mg/ml in 20 mM Tris , pH 8.0. |
Reconstitution : | Add 0.2 ml of deionized H2O and let the lyophilized pellet dissolve completely. |
Stability/Shelf Life : | The lyophilized protein remains stable until the expiry date when stored at -20°C. |
Applications : | Western blotting, ELISA. |
Storage : | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
Gene Name : | REG4 regenerating islet-derived family, member 4 [ Homo sapiens ] |
Synonyms : | REG4; GISP; REG-IV; RELP; OTTHUMP00000014030; OTTHUMP00000014031; Reg IV; REG-like protein; regenerating gene type IV; Gastrointestinal secretory protein; regenerating islet-derived family, member 4; Regenerating islet-derived family, member 4 |
Gene ID : | 83998 |
mRNA Refseq : | NM_001159352 |
Protein Refseq : | NP_001152824 |
MIM : | 609846 |
UniProt ID : | Q9BYZ8 |
Chromosome Location : | 1p13.1-p12 |
Function : | binding; sugar binding |
Products Types
◆ Recombinant Protein | ||
Reg4-8748R | Recombinant Rat Reg4 protein(Met1-Pro157), hFc-tagged | +Inquiry |
Reg4-7474R | Recombinant Rat Reg4 protein(Met1-Pro157), His-tagged | +Inquiry |
REG4-424H | Recombinant Human REG4 Protein, His-tagged | +Inquiry |
REG4-4650R | Recombinant Rat REG4 Protein, His (Fc)-Avi-tagged | +Inquiry |
REG4-697H | Recombinant Human REG4 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
REG4-2111MCL | Recombinant Mouse REG4 cell lysate | +Inquiry |
REG4-979HCL | Recombinant Human REG4 cell lysate | +Inquiry |
REG4-1328RCL | Recombinant Rat REG4 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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